Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2- halo-N-phenyl benzamides and acyclic 1,3-diketones

Veerababurao Kavala, Cheng Chuan Wang, Deepak Kumar Barange, Chun Wei Kuo, Po Min Lei, Ching Fa Yao

Research output: Contribution to journalArticle

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Abstract

A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C-C/C-O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated.

Original languageEnglish
Pages (from-to)5022-5029
Number of pages8
JournalJournal of Organic Chemistry
Volume77
Issue number11
DOIs
Publication statusPublished - 2012 Jun 1

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Isocoumarins
Benzamides
Cyclization
Copper
Derivatives
Substrates

ASJC Scopus subject areas

  • Organic Chemistry

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Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2- halo-N-phenyl benzamides and acyclic 1,3-diketones. / Kavala, Veerababurao; Wang, Cheng Chuan; Barange, Deepak Kumar; Kuo, Chun Wei; Lei, Po Min; Yao, Ching Fa.

In: Journal of Organic Chemistry, Vol. 77, No. 11, 01.06.2012, p. 5022-5029.

Research output: Contribution to journalArticle

Kavala, Veerababurao ; Wang, Cheng Chuan ; Barange, Deepak Kumar ; Kuo, Chun Wei ; Lei, Po Min ; Yao, Ching Fa. / Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2- halo-N-phenyl benzamides and acyclic 1,3-diketones. In: Journal of Organic Chemistry. 2012 ; Vol. 77, No. 11. pp. 5022-5029.
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