Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2- halo-N-phenyl benzamides and acyclic 1,3-diketones

Veerababurao Kavala, Cheng Chuan Wang, Deepak Kumar Barange, Chun Wei Kuo, Po Min Lei, Ching Fa Yao

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82 Citations (Scopus)

Abstract

A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C-C/C-O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated.

Original languageEnglish
Pages (from-to)5022-5029
Number of pages8
JournalJournal of Organic Chemistry
Volume77
Issue number11
DOIs
Publication statusPublished - 2012 Jun 1

ASJC Scopus subject areas

  • Organic Chemistry

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