Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and their application in the synthesis of trisubstituted pyridines

Vijayalakshmi Bandi, Veerababurao Kavala, Che Hao Hsu, Ashok Konala, Bharath Kumar Villuri, Trimurtulu Kotipalli, Chun Wei Kuo, Ching Fa Yao

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An approach for the synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives is reported starting from β-halo styrene and phenyl acetylene derivatives in the presence of PdCl2 and CuI catalysts. Functional groups such as aldehyde, cyano and ester groups are well tolerated and afford the desired functionalized dienynes. Further, these 1,3-buta-diene-3-yne derivatives are utilized for the synthesis of novel trisubstituted pyridine derivatives.

Original languageEnglish
Pages (from-to)46704-46712
Number of pages9
JournalRSC Advances
Issue number74
Publication statusPublished - 2017 Jan 1


ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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