TY - JOUR
T1 - Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and their application in the synthesis of trisubstituted pyridines
AU - Bandi, Vijayalakshmi
AU - Kavala, Veerababurao
AU - Hsu, Che Hao
AU - Konala, Ashok
AU - Villuri, Bharath Kumar
AU - Kotipalli, Trimurtulu
AU - Kuo, Chun Wei
AU - Yao, Ching Fa
N1 - Funding Information:
Financial support by the Ministry of Science and Technology of the Republic of China (MOST 103-2113-M-003-008-MY3), National Taiwan Normal University (103-07-C) and Instrumentation Centre at National Taiwan Normal University is gratefully acknowledged. The authors are grateful to Ms. Hsiu-Ni Huan, Ms. Chiu-Hui He and Ting-Shen Kuo for providing HRMS, NMR spectral and Crystallographic data respectively.
PY - 2017
Y1 - 2017
N2 - An approach for the synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives is reported starting from β-halo styrene and phenyl acetylene derivatives in the presence of PdCl2 and CuI catalysts. Functional groups such as aldehyde, cyano and ester groups are well tolerated and afford the desired functionalized dienynes. Further, these 1,3-buta-diene-3-yne derivatives are utilized for the synthesis of novel trisubstituted pyridine derivatives.
AB - An approach for the synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives is reported starting from β-halo styrene and phenyl acetylene derivatives in the presence of PdCl2 and CuI catalysts. Functional groups such as aldehyde, cyano and ester groups are well tolerated and afford the desired functionalized dienynes. Further, these 1,3-buta-diene-3-yne derivatives are utilized for the synthesis of novel trisubstituted pyridine derivatives.
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U2 - 10.1039/c7ra07128k
DO - 10.1039/c7ra07128k
M3 - Article
AN - SCOPUS:85030787222
VL - 7
SP - 46704
EP - 46712
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 74
ER -