Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway

Yan Cheng Liou, Praneeth Karanam, Yeong Jiunn Jang, Wenwei Lin

Research output: Contribution to journalArticle

Abstract

An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, and a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction is also demonstrated under catalytic conditions with similar efficacy.

Original languageEnglish
Pages (from-to)8008-8012
Number of pages5
JournalOrganic Letters
Volume21
Issue number19
DOIs
Publication statusPublished - 2019 Oct 4

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phosphine
Benzofurans
acylation
Acylation
quinones
Chlorides
Metals
synthesis
phosphines
chlorides
metals
quinone methide

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway. / Liou, Yan Cheng; Karanam, Praneeth; Jang, Yeong Jiunn; Lin, Wenwei.

In: Organic Letters, Vol. 21, No. 19, 04.10.2019, p. 8008-8012.

Research output: Contribution to journalArticle

Liou, Yan Cheng ; Karanam, Praneeth ; Jang, Yeong Jiunn ; Lin, Wenwei. / Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway. In: Organic Letters. 2019 ; Vol. 21, No. 19. pp. 8008-8012.
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