Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/ O-Acylation/Wittig Pathway

Yan Cheng Liou, Praneeth Karanam, Yeong Jiunn Jang, Wenwei Lin

Research output: Contribution to journalArticle


An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, and a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction is also demonstrated under catalytic conditions with similar efficacy.

Original languageEnglish
Pages (from-to)8008-8012
Number of pages5
JournalOrganic Letters
Issue number19
Publication statusPublished - 2019 Oct 4


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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