Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides

Veerababurao Kavala, Zonghan Yang, Ashok Konala, Chia Yu Huang, Chun Wei Kuo, Ching Fa Yao

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An efficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcyanides has been developed. Using this protocol, benzo-fused pyridoindolone derivatives are obtained in high yields in a relatively short period of time under mild reaction conditions. To the best of our knowledge, this is the first approach where one can synthesize free indole N-H benzo-fused pyridoindolones. Also, both indole and pyridone cores are constructed during the course of the reaction. The methodology shows good functional group tolerance and allows synthesis of thiophene-fused pyridoindolones and fused indolobenzonaphthyridone derivatives.

Original languageEnglish
Pages (from-to)7280-7286
Number of pages7
JournalJournal of Organic Chemistry
Issue number14
Publication statusPublished - 2017 Jul 21


ASJC Scopus subject areas

  • Organic Chemistry

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