Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides

Veerababurao Kavala, Zonghan Yang, Ashok Konala, Chia Yu Huang, Chun Wei Kuo, Ching Fa Yao

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

An efficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcyanides has been developed. Using this protocol, benzo-fused pyridoindolone derivatives are obtained in high yields in a relatively short period of time under mild reaction conditions. To the best of our knowledge, this is the first approach where one can synthesize free indole N-H benzo-fused pyridoindolones. Also, both indole and pyridone cores are constructed during the course of the reaction. The methodology shows good functional group tolerance and allows synthesis of thiophene-fused pyridoindolones and fused indolobenzonaphthyridone derivatives.

Original languageEnglish
Pages (from-to)7280-7286
Number of pages7
JournalJournal of Organic Chemistry
Volume82
Issue number14
DOIs
Publication statusPublished - 2017 Jul 21

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Copper
Pyridones
Derivatives
Thiophenes
Functional groups
indole

ASJC Scopus subject areas

  • Organic Chemistry

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Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides. / Kavala, Veerababurao; Yang, Zonghan; Konala, Ashok; Huang, Chia Yu; Kuo, Chun Wei; Yao, Ching Fa.

In: Journal of Organic Chemistry, Vol. 82, No. 14, 21.07.2017, p. 7280-7286.

Research output: Contribution to journalArticle

Kavala, Veerababurao ; Yang, Zonghan ; Konala, Ashok ; Huang, Chia Yu ; Kuo, Chun Wei ; Yao, Ching Fa. / Synthesis of Benzopyridoindolone Derivatives via a One-Pot Copper Catalyzed Tandem Reaction of 2-Iodobenzamide Derivatives and 2-Iodobenzylcyanides. In: Journal of Organic Chemistry. 2017 ; Vol. 82, No. 14. pp. 7280-7286.
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AU - Kuo, Chun Wei

AU - Yao, Ching Fa

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