Abstract
6-Cyanouracil derivatives underwent a direct nucleophilic substitution reaction with alkyl Grignard reagents in the presence of zinc(II) chloride as a catalyst to form the corresponding 6-alkyluracils. This methodology is applicable to sugar-protected 6-cyanouridine and 6-cyano-2′-deoxyuridine without the protection at the N3-imide and provides a facile and general access to versatile 6-alkyluracil and 6-alkyluridine derivatives.
Original language | English |
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Pages (from-to) | 4027-4036 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 78 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2013 Apr 19 |
ASJC Scopus subject areas
- Organic Chemistry