Synthesis of 3-arylindole derivatives from nitroalkane precursors

Chia Yu Huang; Chun Wei Kuo; Ashok Konala; Tang Hao Yang; Lyu Lin; Yu Wen Chen; Veerababurao Kavala; Ching Fa Yao

doi:10.1039/c6ra21144e

Synthesis of 3-arylindole derivatives from nitroalkane precursors

Chia Yu Huang, Chun Wei Kuo, Ashok Konala, Tang Hao Yang, Lyu Lin, Yu Wen Chen, Veerababurao Kavala, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

3-Arylindole derivatives were synthesized by Cu(i) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl₃-mediated Friedel-Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

Original language	English
Pages (from-to)	96049-96056
Number of pages	8
Journal	RSC Advances
Volume	6
Issue number	98
DOIs	https://doi.org/10.1039/c6ra21144e
Publication status	Published - 2016

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Synthesis of 3-arylindole derivatives from nitroalkane precursors",

abstract = "3-Arylindole derivatives were synthesized by Cu(i) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel-Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.",

author = "Huang, {Chia Yu} and Kuo, {Chun Wei} and Ashok Konala and Yang, {Tang Hao} and Lyu Lin and Chen, {Yu Wen} and Veerababurao Kavala and Yao, {Ching Fa}",

note = "Publisher Copyright: {\textcopyright} 2016 The Royal Society of Chemistry.",

year = "2016",

doi = "10.1039/c6ra21144e",

language = "English",

volume = "6",

pages = "96049--96056",

journal = "RSC Advances",

issn = "2046-2069",

publisher = "Royal Society of Chemistry",

number = "98",

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TY - JOUR

T1 - Synthesis of 3-arylindole derivatives from nitroalkane precursors

AU - Huang, Chia Yu

AU - Kuo, Chun Wei

AU - Konala, Ashok

AU - Yang, Tang Hao

AU - Lin, Lyu

AU - Chen, Yu Wen

AU - Kavala, Veerababurao

AU - Yao, Ching Fa

PY - 2016

Y1 - 2016

N2 - 3-Arylindole derivatives were synthesized by Cu(i) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel-Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

AB - 3-Arylindole derivatives were synthesized by Cu(i) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel-Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

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UR - http://www.scopus.com/inward/citedby.url?scp=84991575847&partnerID=8YFLogxK

U2 - 10.1039/c6ra21144e

DO - 10.1039/c6ra21144e

M3 - Article

AN - SCOPUS:84991575847

SN - 2046-2069

VL - 6

SP - 96049

EP - 96056

JO - RSC Advances

JF - RSC Advances

IS - 98

ER -

Synthesis of 3-arylindole derivatives from nitroalkane precursors

Abstract

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