Abstract
Organocatalytic domino Michael-hemiacetalization of β-tetralones with α,β-unsaturated aldehydes is presented. Treatment of β-tetralones with α,β-unsaturated aldehydes in the presence of diphenylprolinol silyl ether gave 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f] chromen-3-ol derivatives with high to excellent chemical yields (50-99%) and high levels of enantioselectivities (up to 96% ee).
| Original language | English |
|---|---|
| Pages (from-to) | 7510-7516 |
| Number of pages | 7 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2011 Nov 7 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Dive into the research topics of 'Synthesis of 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f]chromen-3-ol derivatives from β-tetralones and α,β-unsaturated aldehydes'. Together they form a unique fingerprint.Datasets
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CCDC 824118: Experimental Crystal Structure Determination
Chen, J. (Creator), Chang, C. (Creator), Chang, H. (Creator) & Chen, K. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccwnkgj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccwnkgj&sid=DataCite
Dataset
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CCDC 824119: Experimental Crystal Structure Determination
Chen, J. (Creator), Chang, C. (Creator), Chang, H. (Creator) & Chen, K. (Creator), Unknown Publisher, 2012
DOI: 10.5517/ccwnkhk, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccwnkhk&sid=DataCite
Dataset