Abstract
Organocatalytic domino Michael-hemiacetalization of β-tetralones with α,β-unsaturated aldehydes is presented. Treatment of β-tetralones with α,β-unsaturated aldehydes in the presence of diphenylprolinol silyl ether gave 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f] chromen-3-ol derivatives with high to excellent chemical yields (50-99%) and high levels of enantioselectivities (up to 96% ee).
| Original language | English |
|---|---|
| Pages (from-to) | 7510-7516 |
| Number of pages | 7 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 2011 Nov 7 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Synthesis of 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f]chromen-3-ol derivatives from β-tetralones and α,β-unsaturated aldehydes. / Chen, Jung Hsuan; Chang, Chihliang; Chang, Hui Ju; Chen, Kwunmin.
In: Organic and Biomolecular Chemistry, Vol. 9, No. 21, 07.11.2011, p. 7510-7516.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Synthesis of 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f]chromen-3-ol derivatives from β-tetralones and α,β-unsaturated aldehydes
AU - Chen, Jung Hsuan
AU - Chang, Chihliang
AU - Chang, Hui Ju
AU - Chen, Kwunmin
PY - 2011/11/7
Y1 - 2011/11/7
N2 - Organocatalytic domino Michael-hemiacetalization of β-tetralones with α,β-unsaturated aldehydes is presented. Treatment of β-tetralones with α,β-unsaturated aldehydes in the presence of diphenylprolinol silyl ether gave 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f] chromen-3-ol derivatives with high to excellent chemical yields (50-99%) and high levels of enantioselectivities (up to 96% ee).
AB - Organocatalytic domino Michael-hemiacetalization of β-tetralones with α,β-unsaturated aldehydes is presented. Treatment of β-tetralones with α,β-unsaturated aldehydes in the presence of diphenylprolinol silyl ether gave 2,3,5,6-tetrahydro-1-alkyl/aryl-1H-benzo[f] chromen-3-ol derivatives with high to excellent chemical yields (50-99%) and high levels of enantioselectivities (up to 96% ee).
UR - http://www.scopus.com/inward/record.url?scp=80053953751&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053953751&partnerID=8YFLogxK
U2 - 10.1039/c1ob05966a
DO - 10.1039/c1ob05966a
M3 - Article
C2 - 21931922
AN - SCOPUS:80053953751
VL - 9
SP - 7510
EP - 7516
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 21
ER -