TY - JOUR
T1 - Synthesis of 2,3-Disubstituted Quinazolinone Derivatives through Copper Catalyzed C-H Amidation Reactions
AU - Kotipalli, Trimurtulu
AU - Kavala, Veerababurao
AU - Janreddy, Donala
AU - Bandi, Vijayalakshmi
AU - Kuo, Chun Wei
AU - Yao, Ching Fa
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The synthesis of quinazolinone derivatives was achieved from 2-iodobenzamide derivatives and various benzylamines, allylamine, and cinnamylamine derivatives through a one-pot copper-catalyzed reaction. In this reaction, the amine component (benzylamine/allylamine/cinnamylamine) is N-arylated with 2-iodobenzamide derivatives through Ullman coupling, followed by an intramolecular C-H amidation in the presence of copper catalyst. Copper-catalyzed tandem-Ullman N-alkylation and intramolecular C-H amidation reaction protocol for the synthesis of 2-phenylquinazolinone and quinazolinone derivatives from N-substituted 2-iodo-benzamides and benzylamines, allyl, and cinnamylamine is achieved.
AB - The synthesis of quinazolinone derivatives was achieved from 2-iodobenzamide derivatives and various benzylamines, allylamine, and cinnamylamine derivatives through a one-pot copper-catalyzed reaction. In this reaction, the amine component (benzylamine/allylamine/cinnamylamine) is N-arylated with 2-iodobenzamide derivatives through Ullman coupling, followed by an intramolecular C-H amidation in the presence of copper catalyst. Copper-catalyzed tandem-Ullman N-alkylation and intramolecular C-H amidation reaction protocol for the synthesis of 2-phenylquinazolinone and quinazolinone derivatives from N-substituted 2-iodo-benzamides and benzylamines, allyl, and cinnamylamine is achieved.
KW - Amides
KW - Copper
KW - Homogeneous catalysis
KW - Nitrogen heterocycles
KW - Synthetic methods
UR - http://www.scopus.com/inward/record.url?scp=84959111434&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959111434&partnerID=8YFLogxK
U2 - 10.1002/ejoc.201501552
DO - 10.1002/ejoc.201501552
M3 - Article
AN - SCOPUS:84959111434
VL - 2016
SP - 1182
EP - 1193
JO - Annalen der Pharmacie
JF - Annalen der Pharmacie
SN - 0075-4617
IS - 6
ER -