Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala, Zonghan Yang, Ashok Konala, Tang Hao Yang, Chun Wei Kuo, Jian Yao Ruan, Ching Fa Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

Original languageEnglish
Pages (from-to)1241-1247
Number of pages7
JournalEuropean Journal of Organic Chemistry
Issue number10
Publication statusPublished - 2018 Mar 14


  • Copper
  • Domino reactions
  • Nitrogen heterocycles
  • Polycycles
  • Synthetic methods

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction'. Together they form a unique fingerprint.

Cite this