Abstract
A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.
| Original language | English |
|---|---|
| Pages (from-to) | 1241-1247 |
| Number of pages | 7 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2018 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2018 Mar 14 |
Keywords
- Copper
- Domino reactions
- Nitrogen heterocycles
- Polycycles
- Synthetic methods
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
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Cite this
Kavala, V., Yang, Z., Konala, A., Yang, T. H., Kuo, C. W., Ruan, J. Y., & Yao, C. F. (2018). Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction. European Journal of Organic Chemistry, 2018(10), 1241-1247. https://doi.org/10.1002/ejoc.201701618