Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala; Zonghan Yang; Ashok Konala; Tang Hao Yang; Chun Wei Kuo; Jian Yao Ruan; Ching Fa Yao

doi:10.1002/ejoc.201701618

Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala, Zonghan Yang, Ashok Konala, Tang Hao Yang, Chun Wei Kuo, Jian Yao Ruan, Ching Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

Original language	English
Pages (from-to)	1241-1247
Number of pages	7
Journal	European Journal of Organic Chemistry
Volume	2018
Issue number	10
DOIs	https://doi.org/10.1002/ejoc.201701618
Publication status	Published - 2018 Mar 14

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Keywords

Copper
Domino reactions
Nitrogen heterocycles
Polycycles
Synthetic methods

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Kavala, V., Yang, Z., Konala, A., Yang, T. H., Kuo, C. W., Ruan, J. Y., & Yao, C. F. (2018). Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction. European Journal of Organic Chemistry, 2018(10), 1241-1247. https://doi.org/10.1002/ejoc.201701618

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AU - Yang, Tang Hao

AU - Kuo, Chun Wei

AU - Ruan, Jian Yao

AU - Yao, Ching Fa

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KW - Nitrogen heterocycles

KW - Polycycles

KW - Synthetic methods

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10.1002/ejoc.201701618