Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction

Veerababurao Kavala, Zonghan Yang, Ashok Konala, Tang Hao Yang, Chun Wei Kuo, Jian Yao Ruan, Ching Fa Yao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A one-pot reaction has been devloped for the preparation of 1,2,3-fused indole polyheterocycles by starting from 2-iodobenzamide and 2-iodobenzyl cyanide in the presence of a copper catalyst. The cascade process involves the efficient formation of one C–C and three C–N bonds. A broad substrate scope, good yields, and short reactions times are key features of this strategy.

Original languageEnglish
Pages (from-to)1241-1247
Number of pages7
JournalEuropean Journal of Organic Chemistry
Volume2018
Issue number10
DOIs
Publication statusPublished - 2018 Mar 14

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indoles
Cyanides
cyanides
reaction time
Copper
cascades
catalysts
copper
preparation
Catalysts
Substrates
synthesis
indole

Keywords

  • Copper
  • Domino reactions
  • Nitrogen heterocycles
  • Polycycles
  • Synthetic methods

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction. / Kavala, Veerababurao; Yang, Zonghan; Konala, Ashok; Yang, Tang Hao; Kuo, Chun Wei; Ruan, Jian Yao; Yao, Ching Fa.

In: European Journal of Organic Chemistry, Vol. 2018, No. 10, 14.03.2018, p. 1241-1247.

Research output: Contribution to journalArticle

Kavala, Veerababurao ; Yang, Zonghan ; Konala, Ashok ; Yang, Tang Hao ; Kuo, Chun Wei ; Ruan, Jian Yao ; Yao, Ching Fa. / Synthesis of 1,2,3-Fused Indole Polyheterocycles by Copper-Catalyzed Cascade Reaction. In: European Journal of Organic Chemistry. 2018 ; Vol. 2018, No. 10. pp. 1241-1247.
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AU - Yao, Ching Fa

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