Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li; Shivaji V. More; Chie Hong Wang; Ya Ching Jen; Ching Fa Yao; Tein Fu Wang; Chin Chun Hung; Shu Chuan Jao

doi:10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li^*
, Shivaji V. More
, Chie Hong Wang
, Ya Ching Jen
, Ching Fa Yao
, Tein Fu Wang
, Chin Chun Hung
, Shu Chuan Jao

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original language	English
Pages (from-to)	1148-1152
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.017
Publication status	Published - 2010 Feb 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cancer agents
Drug discovery
Structure-activity relationship
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2009.12.017

Cite this

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title = "Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents",

abstract = "This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.",

keywords = "Anti-cancer agents, Drug discovery, Structure-activity relationship, Synthesis",

author = "Li, \{Wen Shan\} and More, \{Shivaji V.\} and Wang, \{Chie Hong\} and Jen, \{Ya Ching\} and Yao, \{Ching Fa\} and Wang, \{Tein Fu\} and Hung, \{Chin Chun\} and Jao, \{Shu Chuan\}",

note = "Funding Information: We are grateful to Ping-Yu Lin and Dr. Mei-Chun Tseng for assistance with mass spectrometry. We thank the National Science Council ( NSC 95-2113-M-001-018-MY3 ) and Academia Sinica (program project AS-95-TP-AB1) for financial support. ",

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doi = "10.1016/j.bmcl.2009.12.017",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

AU - Li, Wen Shan

AU - More, Shivaji V.

AU - Wang, Chie Hong

AU - Jen, Ya Ching

AU - Yao, Ching Fa

AU - Wang, Tein Fu

AU - Hung, Chin Chun

AU - Jao, Shu Chuan

N1 - Funding Information: We are grateful to Ping-Yu Lin and Dr. Mei-Chun Tseng for assistance with mass spectrometry. We thank the National Science Council ( NSC 95-2113-M-001-018-MY3 ) and Academia Sinica (program project AS-95-TP-AB1) for financial support.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

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KW - Anti-cancer agents

KW - Drug discovery

KW - Structure-activity relationship

KW - Synthesis

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M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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