Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

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10 Citations (Scopus)


This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original languageEnglish
Pages (from-to)1148-1152
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Issue number3
Publication statusPublished - 2010 Feb 1



  • Anti-cancer agents
  • Drug discovery
  • Structure-activity relationship
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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