Abstract
This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.
Original language | English |
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Pages (from-to) | 1148-1152 |
Number of pages | 5 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 20 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 Feb 1 |
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Keywords
- Anti-cancer agents
- Drug discovery
- Structure-activity relationship
- Synthesis
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. / Li, Wen Shan; More, Shivaji V.; Wang, Chie Hong; Jen, Ya Ching; Yao, Ching Fa; Wang, Tein Fu; Hung, Chin Chun; Jao, Shu Chuan.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 1148-1152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents
AU - Li, Wen Shan
AU - More, Shivaji V.
AU - Wang, Chie Hong
AU - Jen, Ya Ching
AU - Yao, Ching Fa
AU - Wang, Tein Fu
AU - Hung, Chin Chun
AU - Jao, Shu Chuan
PY - 2010/2/1
Y1 - 2010/2/1
N2 - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.
AB - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.
KW - Anti-cancer agents
KW - Drug discovery
KW - Structure-activity relationship
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=74049164892&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=74049164892&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2009.12.017
DO - 10.1016/j.bmcl.2009.12.017
M3 - Article
C2 - 20022505
AN - SCOPUS:74049164892
VL - 20
SP - 1148
EP - 1152
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 3
ER -