Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li; Shivaji V. More; Chie Hong Wang; Ya Ching Jen; Ching Fa Yao; Tein Fu Wang; Chin Chun Hung; Shu Chuan Jao

doi:10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original language	English
Pages (from-to)	1148-1152
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.017
Publication status	Published - 2010 Feb 1

Keywords

Anti-cancer agents
Drug discovery
Structure-activity relationship
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. / Li, Wen Shan; More, Shivaji V.; Wang, Chie Hong; Jen, Ya Ching; Yao, Ching Fa; Wang, Tein Fu; Hung, Chin Chun; Jao, Shu Chuan.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 1148-1152.

Research output: Contribution to journal › Article › peer-review

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abstract = "This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.",

keywords = "Anti-cancer agents, Drug discovery, Structure-activity relationship, Synthesis",

author = "Li, {Wen Shan} and More, {Shivaji V.} and Wang, {Chie Hong} and Jen, {Ya Ching} and Yao, {Ching Fa} and Wang, {Tein Fu} and Hung, {Chin Chun} and Jao, {Shu Chuan}",

note = "Funding Information: We are grateful to Ping-Yu Lin and Dr. Mei-Chun Tseng for assistance with mass spectrometry. We thank the National Science Council ( NSC 95-2113-M-001-018-MY3 ) and Academia Sinica (program project AS-95-TP-AB1) for financial support. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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doi = "10.1016/j.bmcl.2009.12.017",

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AU - Li, Wen Shan

AU - More, Shivaji V.

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AU - Jen, Ya Ching

AU - Yao, Ching Fa

AU - Wang, Tein Fu

AU - Hung, Chin Chun

AU - Jao, Shu Chuan

N1 - Funding Information: We are grateful to Ping-Yu Lin and Dr. Mei-Chun Tseng for assistance with mass spectrometry. We thank the National Science Council ( NSC 95-2113-M-001-018-MY3 ) and Academia Sinica (program project AS-95-TP-AB1) for financial support. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

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KW - Drug discovery

KW - Structure-activity relationship

KW - Synthesis

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Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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