Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original languageEnglish
Pages (from-to)1148-1152
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number3
DOIs
Publication statusPublished - 2010 Feb 1

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Oxadiazoles
Diamide
Structure-Activity Relationship
Electrons
Neoplasms

Keywords

  • Anti-cancer agents
  • Drug discovery
  • Structure-activity relationship
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. / Li, Wen Shan; More, Shivaji V.; Wang, Chie Hong; Jen, Ya Ching; Yao, Ching Fa; Wang, Tein Fu; Hung, Chin Chun; Jao, Shu Chuan.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 1148-1152.

Research output: Contribution to journalArticle

Li, Wen Shan ; More, Shivaji V. ; Wang, Chie Hong ; Jen, Ya Ching ; Yao, Ching Fa ; Wang, Tein Fu ; Hung, Chin Chun ; Jao, Shu Chuan. / Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 3. pp. 1148-1152.
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