Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li; Shivaji V. More; Chie Hong Wang; Ya Ching Jen; Ching Fa Yao; Tein Fu Wang; Chin Chun Hung; Shu Chuan Jao

doi:10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original language	English
Pages (from-to)	1148-1152
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.017
Publication status	Published - 2010 Feb 1

Keywords

Anti-cancer agents
Drug discovery
Structure-activity relationship
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. / Li, Wen Shan; More, Shivaji V.; Wang, Chie Hong; Jen, Ya Ching; Yao, Ching Fa; Wang, Tein Fu; Hung, Chin Chun; Jao, Shu Chuan.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 1148-1152.

Research output: Contribution to journal › Article › peer-review

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abstract = "This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.",

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AU - Wang, Tein Fu

AU - Hung, Chin Chun

AU - Jao, Shu Chuan

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