Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li; Shivaji V. More; Chie Hong Wang; Ya Ching Jen; Ching Fa Yao; Tein Fu Wang; Chin Chun Hung; Shu Chuan Jao

doi:10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

Wen Shan Li, Shivaji V. More, Chie Hong Wang, Ya Ching Jen, Ching Fa Yao, Tein Fu Wang, Chin Chun Hung, Shu Chuan Jao

Department of Chemistry

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

Original language	English
Pages (from-to)	1148-1152
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/j.bmcl.2009.12.017
Publication status	Published - 2010 Feb 1

Fingerprint

Oxadiazoles

Diamide

Structure-Activity Relationship

Electrons

Neoplasms

Keywords

Anti-cancer agents
Drug discovery
Structure-activity relationship
Synthesis

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Cite this

Li, W. S., More, S. V., Wang, C. H., Jen, Y. C., Yao, C. F., Wang, T. F., ... Jao, S. C. (2010). Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. Bioorganic and Medicinal Chemistry Letters, 20(3), 1148-1152. https://doi.org/10.1016/j.bmcl.2009.12.017

Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. / Li, Wen Shan; More, Shivaji V.; Wang, Chie Hong; Jen, Ya Ching; Yao, Ching Fa; Wang, Tein Fu; Hung, Chin Chun; Jao, Shu Chuan.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 3, 01.02.2010, p. 1148-1152.

Research output: Contribution to journal › Article

Li, WS, More, SV, Wang, CH, Jen, YC, Yao, CF, Wang, TF, Hung, CC & Jao, SC 2010, 'Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents', Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 3, pp. 1148-1152. https://doi.org/10.1016/j.bmcl.2009.12.017

Li WS, More SV, Wang CH, Jen YC, Yao CF, Wang TF et al. Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. Bioorganic and Medicinal Chemistry Letters. 2010 Feb 1;20(3):1148-1152. https://doi.org/10.1016/j.bmcl.2009.12.017

Li, Wen Shan ; More, Shivaji V. ; Wang, Chie Hong ; Jen, Ya Ching ; Yao, Ching Fa ; Wang, Tein Fu ; Hung, Chin Chun ; Jao, Shu Chuan. / Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 3. pp. 1148-1152.

@article{82cba23345064009b0ef815ba0daa158,

title = "Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents",

abstract = "This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.",

keywords = "Anti-cancer agents, Drug discovery, Structure-activity relationship, Synthesis",

author = "Li, {Wen Shan} and More, {Shivaji V.} and Wang, {Chie Hong} and Jen, {Ya Ching} and Yao, {Ching Fa} and Wang, {Tein Fu} and Hung, {Chin Chun} and Jao, {Shu Chuan}",

year = "2010",

month = "2",

day = "1",

doi = "10.1016/j.bmcl.2009.12.017",

language = "English",

volume = "20",

pages = "1148--1152",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "3",

}

TY - JOUR

T1 - Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents

AU - Li, Wen Shan

AU - More, Shivaji V.

AU - Wang, Chie Hong

AU - Jen, Ya Ching

AU - Yao, Ching Fa

AU - Wang, Tein Fu

AU - Hung, Chin Chun

AU - Jao, Shu Chuan

PY - 2010/2/1

Y1 - 2010/2/1

N2 - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

AB - This study describes the synthesis and structure-activity relationships of a series of furazan-3,4-diamide analogs. 1,2,5-Oxadiazole ring and electron-withdrawing substituent on the phenyl ring are proposed to be the important elements which contribute to a significant extent maximal potency of anti-proliferation effect.

KW - Anti-cancer agents

KW - Drug discovery

KW - Structure-activity relationship

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=74049164892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74049164892&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2009.12.017

DO - 10.1016/j.bmcl.2009.12.017

M3 - Article

C2 - 20022505

AN - SCOPUS:74049164892

VL - 20

SP - 1148

EP - 1152

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 3

ER -

Access to Document

10.1016/j.bmcl.2009.12.017