Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Paul Knochel; Ming Chang P. Yeh; Scott C. Berk; Jason Talbert

doi:10.1021/jo00245a057

Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Paul Knochel^*
, Ming Chang P. Yeh
, Scott C. Berk
, Jason Talbert

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

666 Citations (Scopus)

Abstract

The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

Original language	English
Pages (from-to)	2390-2392
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	53
Issue number	10
DOIs	https://doi.org/10.1021/jo00245a057
Publication status	Published - 1988 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo00245a057

Cite this

@article{9ba4ff4fb2d0419fab990ca3cbf18c57,

title = "Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI",

abstract = "The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.",

author = "Paul Knochel and Yeh, \{Ming Chang P.\} and Berk, \{Scott C.\} and Jason Talbert",

year = "1988",

month = feb,

day = "1",

doi = "10.1021/jo00245a057",

language = "English",

volume = "53",

pages = "2390--2392",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

AU - Knochel, Paul

AU - Yeh, Ming Chang P.

AU - Berk, Scott C.

AU - Talbert, Jason

PY - 1988/2/1

Y1 - 1988/2/1

N2 - The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

AB - The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

UR - https://www.scopus.com/pages/publications/33845280673

UR - https://www.scopus.com/pages/publications/33845280673#tab=citedBy

U2 - 10.1021/jo00245a057

DO - 10.1021/jo00245a057

M3 - Article

AN - SCOPUS:33845280673

SN - 0022-3263

VL - 53

SP - 2390

EP - 2392

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 10

ER -

Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this