Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Paul Knochel; Ming Chang P. Yeh; Scott C. Berk; Jason Talbert

doi:10.1021/jo00245a057

Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Paul Knochel^*, Ming Chang P. Yeh, Scott C. Berk, Jason Talbert

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

647 Citations (Scopus)

Abstract

The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

Original language	English
Pages (from-to)	2390-2392
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	53
Issue number	10
DOIs	https://doi.org/10.1021/jo00245a057
Publication status	Published - 1988 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo00245a057

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title = "Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI",

abstract = "The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.",

author = "Paul Knochel and Yeh, {Ming Chang P.} and Berk, {Scott C.} and Jason Talbert",

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AU - Knochel, Paul

AU - Yeh, Ming Chang P.

AU - Berk, Scott C.

AU - Talbert, Jason

PY - 1988/2/1

Y1 - 1988/2/1

N2 - The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

AB - The new and highly functionalized copper reagents RCu(CN)ZnI obtained from readily available primary and secondary alkylzinc iodides by a transmetalation in THF with the soluble salt, CuCN-2LiX, react in good yields with acyl chlorides and enones, respectively, to afford ketones and 1,4-addition products.

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Synthesis and Reactivity toward Acyl Chlorides and Enones of the New Highly Functionalized Copper Reagents RCu(CN)ZnI

Abstract

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