Synthesis and biological evaluation of new spirooxindoles with embedded pharmacophores

Sadasivam Mathusalini, Thangaraj Arasakumar, Krishnasamy Lakshmi, Chia Her Lin, Palathurai Subramaniam Mohan*, Madhusudhanan Gogul Ramnath, Ramaraj Thirugnanasampandan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A regioselective synthesis of new mono and bisoxindoles containing bis spiro heterocyclic hybrids has been envisaged via 1,3-dipolar cycloaddition of azomethine ylides with the dipolarophile (E)-3-((2-methoxyquinolin-3-yl)methylene)indolin-2-one, obtained through the base catalyzed condensation of indolin-2-one with substituted 2-methoxyquinoline-3-carbaldehyde. The regiochemistry and stereochemistry of the synthesized products were characterized by 1D and 2D NMR techniques and single crystal X-ray diffraction studies. Many of the compounds were found to show in vitro antioxidant, antidiabetic and acetylcholinesterase inhibitory activities.

Original languageEnglish
Pages (from-to)5164-5169
Number of pages6
JournalNew Journal of Chemistry
Volume40
Issue number6
DOIs
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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