Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl

Wen Chang Chen, Chan Chieh Lin, Veerababurao Kavala, Chun Wei Kuo, Chia Yu Huang, Ching Fa Yao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An easy and efficient procedure for the synthesis of 4-indolylquinoline derivatives is described. This process involves two steps, the first of which is the Michael addition of indole to nitrochalcones promoted by sulfamic acid under solvent free conditions and the second step is a reductive cyclization of the indolylnitrochalcone intermediates to 4-indolylquinoline derivatives by Fe/HCl in ethanol. In both steps, the reactions are clean and the yields of products are high.

Original languageEnglish
Pages (from-to)22499-22519
Number of pages21
JournalMolecules
Volume20
Issue number12
DOIs
Publication statusPublished - 2015 Dec 15

Fingerprint

Cyclization
Ethanol
Derivatives
indole
sulfamic acid

Keywords

  • 4-indolylquinoline
  • Fe/HCl
  • Indolylchalcone
  • Reductive cyclization

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl. / Chen, Wen Chang; Lin, Chan Chieh; Kavala, Veerababurao; Kuo, Chun Wei; Huang, Chia Yu; Yao, Ching Fa.

In: Molecules, Vol. 20, No. 12, 15.12.2015, p. 22499-22519.

Research output: Contribution to journalArticle

Chen, Wen Chang ; Lin, Chan Chieh ; Kavala, Veerababurao ; Kuo, Chun Wei ; Huang, Chia Yu ; Yao, Ching Fa. / Syntheses of 4-indolylquinoline derivatives via reductive cyclization of indolylnitrochalcone derivatives by Fe/HCl. In: Molecules. 2015 ; Vol. 20, No. 12. pp. 22499-22519.
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