Susceptibility to Exercise-Induced Muscle Damage: A Cluster Analysis with a Large Sample

F. Damas, K. Nosaka, C. A. Libardi, Chung-Ching Chen, C. Ugrinowitsch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the responses of indirect markers of exercise-induced muscle damage (EIMD) among a large number of young men (N=286) stratified in clusters based on the largest decrease in maximal voluntary contraction torque (MVC) after an unaccustomed maximal eccentric exercise bout of the elbow flexors. Changes in MVC, muscle soreness (SOR), creatine kinase (CK) activity, range of motion (ROM) and upper-arm circumference (CIR) before and for several days after exercise were compared between 3 clusters established based on MVC decrease (low, moderate, and high responders; LR, MR and HR). Participants were allocated to LR (n=61), MR (n=152) and HR (n=73) clusters, which depicted significantly different cluster centers of 82%, 61% and 42% of baseline MVC, respectively. Once stratified by MVC decrease, all muscle damage markers were significantly different between clusters following the same pattern: small changes for LR, larger changes for MR, and the largest changes for HR. Stratification of individuals based on the magnitude of MVC decrease post-exercise greatly increases the precision in estimating changes in EIMD by proxy markers such as SOR, CK activity, ROM and CIR. This indicates that the most commonly used markers are valid and MVC orchestrates their responses, consolidating the role of MVC as the best EIMD indirect marker.

Original languageEnglish
Pages (from-to)633-640
Number of pages8
JournalInternational Journal of Sports Medicine
Volume37
Issue number8
DOIs
Publication statusPublished - 2016 Jul 1

Fingerprint

Torque
Cluster Analysis
Exercise
Muscles
Articular Range of Motion
MM Form Creatine Kinase
Myalgia
Proxy
Creatine Kinase
Elbow
Arm

Keywords

  • creatine kinase
  • elbow flexors
  • isometric contraction
  • lengthening contractions
  • muscle soreness
  • range of motion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Susceptibility to Exercise-Induced Muscle Damage : A Cluster Analysis with a Large Sample. / Damas, F.; Nosaka, K.; Libardi, C. A.; Chen, Chung-Ching; Ugrinowitsch, C.

In: International Journal of Sports Medicine, Vol. 37, No. 8, 01.07.2016, p. 633-640.

Research output: Contribution to journalArticle

Damas, F. ; Nosaka, K. ; Libardi, C. A. ; Chen, Chung-Ching ; Ugrinowitsch, C. / Susceptibility to Exercise-Induced Muscle Damage : A Cluster Analysis with a Large Sample. In: International Journal of Sports Medicine. 2016 ; Vol. 37, No. 8. pp. 633-640.
@article{b81b3e9d905440f0ba3d6ab938295546,
title = "Susceptibility to Exercise-Induced Muscle Damage: A Cluster Analysis with a Large Sample",
abstract = "We investigated the responses of indirect markers of exercise-induced muscle damage (EIMD) among a large number of young men (N=286) stratified in clusters based on the largest decrease in maximal voluntary contraction torque (MVC) after an unaccustomed maximal eccentric exercise bout of the elbow flexors. Changes in MVC, muscle soreness (SOR), creatine kinase (CK) activity, range of motion (ROM) and upper-arm circumference (CIR) before and for several days after exercise were compared between 3 clusters established based on MVC decrease (low, moderate, and high responders; LR, MR and HR). Participants were allocated to LR (n=61), MR (n=152) and HR (n=73) clusters, which depicted significantly different cluster centers of 82{\%}, 61{\%} and 42{\%} of baseline MVC, respectively. Once stratified by MVC decrease, all muscle damage markers were significantly different between clusters following the same pattern: small changes for LR, larger changes for MR, and the largest changes for HR. Stratification of individuals based on the magnitude of MVC decrease post-exercise greatly increases the precision in estimating changes in EIMD by proxy markers such as SOR, CK activity, ROM and CIR. This indicates that the most commonly used markers are valid and MVC orchestrates their responses, consolidating the role of MVC as the best EIMD indirect marker.",
keywords = "creatine kinase, elbow flexors, isometric contraction, lengthening contractions, muscle soreness, range of motion",
author = "F. Damas and K. Nosaka and Libardi, {C. A.} and Chung-Ching Chen and C. Ugrinowitsch",
year = "2016",
month = "7",
day = "1",
doi = "10.1055/s-0042-100281",
language = "English",
volume = "37",
pages = "633--640",
journal = "International Journal of Sports Medicine",
issn = "0172-4622",
publisher = "Georg Thieme Verlag",
number = "8",

}

TY - JOUR

T1 - Susceptibility to Exercise-Induced Muscle Damage

T2 - A Cluster Analysis with a Large Sample

AU - Damas, F.

AU - Nosaka, K.

AU - Libardi, C. A.

AU - Chen, Chung-Ching

AU - Ugrinowitsch, C.

PY - 2016/7/1

Y1 - 2016/7/1

N2 - We investigated the responses of indirect markers of exercise-induced muscle damage (EIMD) among a large number of young men (N=286) stratified in clusters based on the largest decrease in maximal voluntary contraction torque (MVC) after an unaccustomed maximal eccentric exercise bout of the elbow flexors. Changes in MVC, muscle soreness (SOR), creatine kinase (CK) activity, range of motion (ROM) and upper-arm circumference (CIR) before and for several days after exercise were compared between 3 clusters established based on MVC decrease (low, moderate, and high responders; LR, MR and HR). Participants were allocated to LR (n=61), MR (n=152) and HR (n=73) clusters, which depicted significantly different cluster centers of 82%, 61% and 42% of baseline MVC, respectively. Once stratified by MVC decrease, all muscle damage markers were significantly different between clusters following the same pattern: small changes for LR, larger changes for MR, and the largest changes for HR. Stratification of individuals based on the magnitude of MVC decrease post-exercise greatly increases the precision in estimating changes in EIMD by proxy markers such as SOR, CK activity, ROM and CIR. This indicates that the most commonly used markers are valid and MVC orchestrates their responses, consolidating the role of MVC as the best EIMD indirect marker.

AB - We investigated the responses of indirect markers of exercise-induced muscle damage (EIMD) among a large number of young men (N=286) stratified in clusters based on the largest decrease in maximal voluntary contraction torque (MVC) after an unaccustomed maximal eccentric exercise bout of the elbow flexors. Changes in MVC, muscle soreness (SOR), creatine kinase (CK) activity, range of motion (ROM) and upper-arm circumference (CIR) before and for several days after exercise were compared between 3 clusters established based on MVC decrease (low, moderate, and high responders; LR, MR and HR). Participants were allocated to LR (n=61), MR (n=152) and HR (n=73) clusters, which depicted significantly different cluster centers of 82%, 61% and 42% of baseline MVC, respectively. Once stratified by MVC decrease, all muscle damage markers were significantly different between clusters following the same pattern: small changes for LR, larger changes for MR, and the largest changes for HR. Stratification of individuals based on the magnitude of MVC decrease post-exercise greatly increases the precision in estimating changes in EIMD by proxy markers such as SOR, CK activity, ROM and CIR. This indicates that the most commonly used markers are valid and MVC orchestrates their responses, consolidating the role of MVC as the best EIMD indirect marker.

KW - creatine kinase

KW - elbow flexors

KW - isometric contraction

KW - lengthening contractions

KW - muscle soreness

KW - range of motion

UR - http://www.scopus.com/inward/record.url?scp=84965054515&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965054515&partnerID=8YFLogxK

U2 - 10.1055/s-0042-100281

DO - 10.1055/s-0042-100281

M3 - Article

C2 - 27116346

AN - SCOPUS:84965054515

VL - 37

SP - 633

EP - 640

JO - International Journal of Sports Medicine

JF - International Journal of Sports Medicine

SN - 0172-4622

IS - 8

ER -