Surface plasmon resonance biochip based on ZnO thin film for nitric oxide sensing

Wei Yi Feng, Nan Fu Chiu, Hui Hsin Lu, Hsueh Ching Shih, Dongfang Yang, Chii Wann Lin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In this study, the design of a novel optical sensor that comprises surface plasmon resonance sensing chip and zinc oxide nano-film was proposed for the detection of nitric oxide gas. The electrical and optical properties of zinc oxide film vary in the presence of nitric oxide. This effect was utilized to prepare biochemical sensors with transduction based on surface plasmon resonance. Due to the refractive index of the transparent zinc oxide film that was deposited on the gold film, however, changes will be observed in the surface plasmon resonance spectra. For this reason, the thickness of zinc oxide film will be investigated and determined in this study. The interaction of nitric oxide with a 20 nm zinc oxide layer on gold leads to the shift of the resonance angle. The analysis on the reflectance intensity of light demonstrates that such effect is caused by the variation of conductivity and permittivity of zinc oxide film. Finally, a shift in surface plasmon resonance angle was measured in 25 ppm nitric oxide at 180 °C and a calibration curve of nitride oxide concentration versus response intensity was successfully obtained in the range of 250 to 1000 ppm nitric oxide at lower temperature of 150 °C. Moreover, these effects are quasi-reversible.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalJournal of Bionanoscience
Issue number1
Publication statusPublished - 2008 Jun
Externally publishedYes


  • Gas sensor
  • Nitric oxide
  • Surface plasmon resonance
  • Zinc oxide
  • ZnO thin film

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biomedical Engineering


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