Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

Jian Bang Lin; Jhih Li He; Yu Chiao Shih; Tun Cheng Chien

doi:10.1016/j.tetlet.2011.05.033

Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

Jian Bang Lin
, Jhih Li He
, Yu Chiao Shih
, Tun Cheng Chien^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

6-Cyanouracil derivatives underwent direct substitution reactions with selective primary amines in the presence of N,N-dimethylaminopyridine as a catalyst to give the corresponding 6-alkylaminouracils. This reaction provides a facile access to versatile 6-alkylaminouridine derivatives.

Original language	English
Pages (from-to)	3969-3972
Number of pages	4
Journal	Tetrahedron Letters
Volume	52
Issue number	31
DOIs	https://doi.org/10.1016/j.tetlet.2011.05.033
Publication status	Published - 2011 Aug 3

Keywords

6-Alkylaminouracil
6-Alkylaminouridine
6-Cyanouracil
6-Cyanouridine
Nucleophilic aromatic substitution

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.05.033

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@article{f1c02105aecf4413b96f698c9e0c00d9,

title = "Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives",

abstract = "6-Cyanouracil derivatives underwent direct substitution reactions with selective primary amines in the presence of N,N-dimethylaminopyridine as a catalyst to give the corresponding 6-alkylaminouracils. This reaction provides a facile access to versatile 6-alkylaminouridine derivatives.",

keywords = "6-Alkylaminouracil, 6-Alkylaminouridine, 6-Cyanouracil, 6-Cyanouridine, Nucleophilic aromatic substitution",

author = "Lin, \{Jian Bang\} and He, \{Jhih Li\} and Shih, \{Yu Chiao\} and Chien, \{Tun Cheng\}",

note = "Funding Information: This work was supported by Research Grant 97-2113-M-003-001-MY2 from the National Science Council , Taiwan. We are grateful to the National Center for High-performance Computing of Taiwan for the electronic resources and facilities. ",

year = "2011",

month = aug,

day = "3",

doi = "10.1016/j.tetlet.2011.05.033",

language = "English",

volume = "52",

pages = "3969--3972",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "31",

}

TY - JOUR

T1 - Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

AU - Lin, Jian Bang

AU - He, Jhih Li

AU - Shih, Yu Chiao

AU - Chien, Tun Cheng

N1 - Funding Information: This work was supported by Research Grant 97-2113-M-003-001-MY2 from the National Science Council , Taiwan. We are grateful to the National Center for High-performance Computing of Taiwan for the electronic resources and facilities.

PY - 2011/8/3

Y1 - 2011/8/3

N2 - 6-Cyanouracil derivatives underwent direct substitution reactions with selective primary amines in the presence of N,N-dimethylaminopyridine as a catalyst to give the corresponding 6-alkylaminouracils. This reaction provides a facile access to versatile 6-alkylaminouridine derivatives.

AB - 6-Cyanouracil derivatives underwent direct substitution reactions with selective primary amines in the presence of N,N-dimethylaminopyridine as a catalyst to give the corresponding 6-alkylaminouracils. This reaction provides a facile access to versatile 6-alkylaminouridine derivatives.

KW - 6-Alkylaminouracil

KW - 6-Alkylaminouridine

KW - 6-Cyanouracil

KW - 6-Cyanouridine

KW - Nucleophilic aromatic substitution

UR - https://www.scopus.com/pages/publications/79959912801

UR - https://www.scopus.com/pages/publications/79959912801#tab=citedBy

U2 - 10.1016/j.tetlet.2011.05.033

DO - 10.1016/j.tetlet.2011.05.033

M3 - Article

AN - SCOPUS:79959912801

SN - 0040-4039

VL - 52

SP - 3969

EP - 3972

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 31

ER -

Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

Abstract

Keywords

ASJC Scopus subject areas

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