Study on the synthesis of 6-alkylaminouridines via the nucleophilic aromatic substitution reaction of 6-cyanouridine derivatives

Jian Bang Lin, Jhih Li He, Yu Chiao Shih, Tun Cheng Chien

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

6-Cyanouracil derivatives underwent direct substitution reactions with selective primary amines in the presence of N,N-dimethylaminopyridine as a catalyst to give the corresponding 6-alkylaminouracils. This reaction provides a facile access to versatile 6-alkylaminouridine derivatives.

Original languageEnglish
Pages (from-to)3969-3972
Number of pages4
JournalTetrahedron Letters
Volume52
Issue number31
DOIs
Publication statusPublished - 2011 Aug 3

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Keywords

  • 6-Alkylaminouracil
  • 6-Alkylaminouridine
  • 6-Cyanouracil
  • 6-Cyanouridine
  • Nucleophilic aromatic substitution

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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