TY - GEN
T1 - Study of γ-Fe2O3/Au core/shell nanoparticles as the contrast agent for high-Tc SQUID-based low field nuclear magnetic resonance
AU - Chen, Kuen Lin
AU - Yeh, Yao Wei
AU - Liao, Shu Hsien
AU - Wu, Chiu Hsien
AU - Wang, Li Min
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/11/21
Y1 - 2016/11/21
N2 - To improve the image contrast, the so-called contrast agents (CAs) are often used in magnetic resonance image (MRI). CAs are generally paramagnetic or superparamagnetic nanoparticle suspensions. To increase the applicability of low field nuclear magnetic resonance (LFNMR) or LFMRI system, CAs also have been introduced to enhance the image contrast. In this work, we synthesized the γ-Fe2O3/Au core/shell (γ-Fe2O3@Au) nanoparticle and applied it to a homemade high-Tc SQUID-based LFNMR system to study the characteristics of γ-Fe2O3@Au nanoparticle as the contrast agent for the LFNMR system. The average hydrodynamic sizes of the synthesized γ-Fe2O3@Au nanoparticles are 28.38 ± 6.26 nm in diameter. The γ-Fe2O3@Au nanoparticles exhibit a characteristic absorption peak at 536 nm from the contribution of localized surface plasmon resonance of Au shell. The spin-lattice relaxation rate, 1/T1, and the spin-spin relaxation rate, 1/T2, varied with the concentration of γ-Fe2O3@Au nanoparticle. Compared with the data measured in high field (7 Tesla), we found that the γ-Fe2O3@Au nanoparticle is a promising T1-relaxing CA for LFNMR.
AB - To improve the image contrast, the so-called contrast agents (CAs) are often used in magnetic resonance image (MRI). CAs are generally paramagnetic or superparamagnetic nanoparticle suspensions. To increase the applicability of low field nuclear magnetic resonance (LFNMR) or LFMRI system, CAs also have been introduced to enhance the image contrast. In this work, we synthesized the γ-Fe2O3/Au core/shell (γ-Fe2O3@Au) nanoparticle and applied it to a homemade high-Tc SQUID-based LFNMR system to study the characteristics of γ-Fe2O3@Au nanoparticle as the contrast agent for the LFNMR system. The average hydrodynamic sizes of the synthesized γ-Fe2O3@Au nanoparticles are 28.38 ± 6.26 nm in diameter. The γ-Fe2O3@Au nanoparticles exhibit a characteristic absorption peak at 536 nm from the contribution of localized surface plasmon resonance of Au shell. The spin-lattice relaxation rate, 1/T1, and the spin-spin relaxation rate, 1/T2, varied with the concentration of γ-Fe2O3@Au nanoparticle. Compared with the data measured in high field (7 Tesla), we found that the γ-Fe2O3@Au nanoparticle is a promising T1-relaxing CA for LFNMR.
UR - http://www.scopus.com/inward/record.url?scp=85006934372&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006934372&partnerID=8YFLogxK
U2 - 10.1109/NANO.2016.7751445
DO - 10.1109/NANO.2016.7751445
M3 - Conference contribution
AN - SCOPUS:85006934372
T3 - 16th International Conference on Nanotechnology - IEEE NANO 2016
SP - 585
EP - 586
BT - 16th International Conference on Nanotechnology - IEEE NANO 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
Y2 - 22 August 2016 through 25 August 2016
ER -