Strategic Exploitation of the Wittig Reaction: Facile Synthesis of Heteroaromatics and Multifunctional Olefins

Praneeth Karanam, Ganapuram Madhusudhan Reddy, Wen-Wei Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)


In this account, our group's efforts towards exploring new substrates as precursors for the Wittig reaction have been discussed. Several new strategies developed by our group for the generation of requisite ylides for the Wittig reaction are highlighted. The idea behind the development of some chemoselective and diversity-oriented strategies are discussed in detail in a progressive manner. These strategies encompass a wide range of substrates that are employed for the synthesis of an array of heterocycles and multifunctional olefins and present a huge scope for their application on an industrial level. 1 Introduction 2 Development of New Methods to Effect Intramolecular Wittig Reaction 3 Development of a Catalytic Wittig Reaction 4 New Synthesis of Bis-Heteroarenes 5 Direct β-Acylation of 2-Arylidene-1,3-indandiones 6 Doubly Chemoselective Protocol for the Diversity-Oriented Synthesis of Coumarin Derivatives 7 Conclusion.

Original languageEnglish
Article numberst-2018-a0339-a
Pages (from-to)2608-2622
Number of pages15
Issue number20
Publication statusPublished - 2018 Dec 17



  • Wittig reaction
  • acylation
  • chemoselectivity
  • diversity-oriented synthesis
  • heteroarene
  • phospha-Michael addition
  • phosphine
  • ylide

ASJC Scopus subject areas

  • Organic Chemistry

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