Abstract
In this account, our group's efforts towards exploring new substrates as precursors for the Wittig reaction have been discussed. Several new strategies developed by our group for the generation of requisite ylides for the Wittig reaction are highlighted. The idea behind the development of some chemoselective and diversity-oriented strategies are discussed in detail in a progressive manner. These strategies encompass a wide range of substrates that are employed for the synthesis of an array of heterocycles and multifunctional olefins and present a huge scope for their application on an industrial level. 1 Introduction 2 Development of New Methods to Effect Intramolecular Wittig Reaction 3 Development of a Catalytic Wittig Reaction 4 New Synthesis of Bis-Heteroarenes 5 Direct β-Acylation of 2-Arylidene-1,3-indandiones 6 Doubly Chemoselective Protocol for the Diversity-Oriented Synthesis of Coumarin Derivatives 7 Conclusion.
| Original language | English |
|---|---|
| Article number | st-2018-a0339-a |
| Pages (from-to) | 2608-2622 |
| Number of pages | 15 |
| Journal | Synlett |
| Volume | 29 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2018 Dec 17 |
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Keywords
- Wittig reaction
- acylation
- chemoselectivity
- diversity-oriented synthesis
- heteroarene
- phospha-Michael addition
- phosphine
- ylide
ASJC Scopus subject areas
- Organic Chemistry
Cite this
Strategic Exploitation of the Wittig Reaction : Facile Synthesis of Heteroaromatics and Multifunctional Olefins. / Karanam, Praneeth; Reddy, Ganapuram Madhusudhan; Lin, Wen-Wei.
In: Synlett, Vol. 29, No. 20, st-2018-a0339-a, 17.12.2018, p. 2608-2622.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strategic Exploitation of the Wittig Reaction
T2 - Facile Synthesis of Heteroaromatics and Multifunctional Olefins
AU - Karanam, Praneeth
AU - Reddy, Ganapuram Madhusudhan
AU - Lin, Wen-Wei
PY - 2018/12/17
Y1 - 2018/12/17
N2 - In this account, our group's efforts towards exploring new substrates as precursors for the Wittig reaction have been discussed. Several new strategies developed by our group for the generation of requisite ylides for the Wittig reaction are highlighted. The idea behind the development of some chemoselective and diversity-oriented strategies are discussed in detail in a progressive manner. These strategies encompass a wide range of substrates that are employed for the synthesis of an array of heterocycles and multifunctional olefins and present a huge scope for their application on an industrial level. 1 Introduction 2 Development of New Methods to Effect Intramolecular Wittig Reaction 3 Development of a Catalytic Wittig Reaction 4 New Synthesis of Bis-Heteroarenes 5 Direct β-Acylation of 2-Arylidene-1,3-indandiones 6 Doubly Chemoselective Protocol for the Diversity-Oriented Synthesis of Coumarin Derivatives 7 Conclusion.
AB - In this account, our group's efforts towards exploring new substrates as precursors for the Wittig reaction have been discussed. Several new strategies developed by our group for the generation of requisite ylides for the Wittig reaction are highlighted. The idea behind the development of some chemoselective and diversity-oriented strategies are discussed in detail in a progressive manner. These strategies encompass a wide range of substrates that are employed for the synthesis of an array of heterocycles and multifunctional olefins and present a huge scope for their application on an industrial level. 1 Introduction 2 Development of New Methods to Effect Intramolecular Wittig Reaction 3 Development of a Catalytic Wittig Reaction 4 New Synthesis of Bis-Heteroarenes 5 Direct β-Acylation of 2-Arylidene-1,3-indandiones 6 Doubly Chemoselective Protocol for the Diversity-Oriented Synthesis of Coumarin Derivatives 7 Conclusion.
KW - Wittig reaction
KW - acylation
KW - chemoselectivity
KW - diversity-oriented synthesis
KW - heteroarene
KW - phospha-Michael addition
KW - phosphine
KW - ylide
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UR - http://www.scopus.com/inward/citedby.url?scp=85058102197&partnerID=8YFLogxK
U2 - 10.1055/s-0037-1610486
DO - 10.1055/s-0037-1610486
M3 - Article
AN - SCOPUS:85058102197
VL - 29
SP - 2608
EP - 2622
JO - Synlett
JF - Synlett
SN - 0936-5214
IS - 20
M1 - st-2018-a0339-a
ER -