Stimulation of MMP-9 of oral epithelial cells by areca nut extract is related to TGF-ß/Smad2-dependent and -independent pathways and prevented by betel leaf extract, hydroxychavicol and melatonin

Mei Chi Chang, Yu Hwa Pan, Hsyueh Liang Wu, Yi Jie Lu, Wan Chuen Liao, Chien Yang Yeh, Jang Jaer Lee, Jiiang Huei Jeng*

*Corresponding author for this work

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Medicine and Dentistry

Pharmacology, Toxicology and Pharmaceutical Science