Abstract
The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one (4) via a three-component reaction of aldehydes (1), anilines (2), and 1-acetylcyclohexene (3) in the presence of iodine in a one-pot reaction at room temperature is described. The short reaction time, easy workup, excellent yield, and mild reaction conditions make this novel annulation strategy both practical and attractive.
| Original language | English |
|---|---|
| Pages (from-to) | 6588-6591 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 71 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2006 Aug 18 |
ASJC Scopus subject areas
- Organic Chemistry
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Dive into the research topics of 'Stereoselective three-component synthesis of trans-endo-decahydroquinolin- 4-one derivatives from aldehydes, aniline, and acetylcyclohexene'. Together they form a unique fingerprint.Datasets
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CCDC 622847: Experimental Crystal Structure Determination
Lin, C. (Creator), Fang, H. (Creator), Tu, Z. (Creator), Liu, J.-T. (Creator) & Yao, C.-F. (Creator), Unknown Publisher, 2006
DOI: 10.5517/ccnx3vh, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccnx3vh&sid=DataCite
Dataset
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CCDC 602079: Experimental Crystal Structure Determination
Lin, C. (Creator), Fang, H. (Creator), Tu, Z. (Creator), Liu, J.-T. (Creator) & Yao, C.-F. (Creator), Unknown Publisher, 2006
DOI: 10.5517/ccn6hx7, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccn6hx7&sid=DataCite
Dataset
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CCDC 602081: Experimental Crystal Structure Determination
Lin, C. (Creator), Fang, H. (Creator), Tu, Z. (Creator), Liu, J.-T. (Creator) & Yao, C.-F. (Creator), Unknown Publisher, 2006
DOI: 10.5517/ccn6hz9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccn6hz9&sid=DataCite
Dataset