Abstract
The diastereoselective synthesis of trans-endo-decahydroquinolin-4-one (4) via a three-component reaction of aldehydes (1), anilines (2), and 1-acetylcyclohexene (3) in the presence of iodine in a one-pot reaction at room temperature is described. The short reaction time, easy workup, excellent yield, and mild reaction conditions make this novel annulation strategy both practical and attractive.
| Original language | English |
|---|---|
| Pages (from-to) | 6588-6591 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 71 |
| Issue number | 17 |
| DOIs | |
| Publication status | Published - 2006 Aug 18 |
ASJC Scopus subject areas
- Organic Chemistry
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Lin, C., Fang, H., Tu, Z., Liu, J. T., & Yao, C. F. (2006). Stereoselective three-component synthesis of trans-endo-decahydroquinolin- 4-one derivatives from aldehydes, aniline, and acetylcyclohexene. Journal of Organic Chemistry, 71(17), 6588-6591. https://doi.org/10.1021/jo060992c