Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis

Hao Hsiang Chang, Yu Kang Chang, Chia Wen Lu, Chi Ting Huang, Chiang Ting Chien, Kuan Yu Hung, Kuo Chin Huang, Chih Cheng Hsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis cohort. A total of 9862 pairs of statin users and non-users, matched by age and gender, were selected for investigation from 75404 new hemodialysis patients during 2000-2008. The effect of statins on permanent hemodialysis access patency was evaluated using Cox proportional hazards models. Compared with non-users, statin users had an overall 18% risk reduction in the composite endpoint in which angioplasty and recreation were combined (adjusted hazard ratio = 0.82 [95%CI, 0.78-0.87]) and 21% in recreation of permanent hemodialysis access (adjusted hazard ratio = 0.79 [95%CI, 0.69-0.80]). Specifically, the protective effect was found for arteriovenous fistula (adjusted hazard ratio = 0.78[95% CI, 0.73-0.82] for composite endpoint and 0.74 [95% CI, 0.69-0.80] for vascular recreation), but not for arteriovenous grafts (adjusted hazard ratio = 1.10 [95% CI, 0.98-1.24] and 0.94 [95% CI, 0.83-1.07]). Statins possess a protective effect for arteriovenous fistula against the recreation of permanent hemodialysis access. The results provide a pharmaco-epidemiologic link between basic research and clinical evidence.

Original languageEnglish
Article number22197
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2016 Feb 23

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Arteriovenous Fistula
Renal Dialysis
Recreation
Risk Reduction Behavior
Angioplasty
Proportional Hazards Models
Blood Vessels
Pathologic Constriction
Transplants
Research

ASJC Scopus subject areas

  • General

Cite this

Chang, H. H., Chang, Y. K., Lu, C. W., Huang, C. T., Chien, C. T., Hung, K. Y., ... Hsu, C. C. (2016). Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis. Scientific Reports, 6, [22197]. https://doi.org/10.1038/srep22197

Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis. / Chang, Hao Hsiang; Chang, Yu Kang; Lu, Chia Wen; Huang, Chi Ting; Chien, Chiang Ting; Hung, Kuan Yu; Huang, Kuo Chin; Hsu, Chih Cheng.

In: Scientific Reports, Vol. 6, 22197, 23.02.2016.

Research output: Contribution to journalArticle

Chang, HH, Chang, YK, Lu, CW, Huang, CT, Chien, CT, Hung, KY, Huang, KC & Hsu, CC 2016, 'Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis', Scientific Reports, vol. 6, 22197. https://doi.org/10.1038/srep22197
Chang, Hao Hsiang ; Chang, Yu Kang ; Lu, Chia Wen ; Huang, Chi Ting ; Chien, Chiang Ting ; Hung, Kuan Yu ; Huang, Kuo Chin ; Hsu, Chih Cheng. / Statins Improve Long Term Patency of Arteriovenous Fistula for Hemodialysis. In: Scientific Reports. 2016 ; Vol. 6.
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