SSRIs associated with decreased risk of hepatocellular carcinoma: A population-based case-control study

Hsiang Lin Chan, Wei Che Chiu, Vincent Chin Hung Chen, Kuo You Huang, Tsu Nai Wang, Yena Lee, Roger S. McIntyre, Tsai Ching Hsu, Charles Tzu Chi Lee, Bor Show Tzang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


Background: Hepatocellular carcinoma (HCC) is the second leading cancer-related cause of mortality worldwide. Antidepressants, especially selective serotonin reuptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited. Objective: The present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population-based study. Methods: The nationwide population-based study herein using Taiwan's National Health Insurance Research Database included a total of 59 859 cases with HCC and 285 124 matched controls. Conditional logistic regression analyses were adjusted for confounding variables. Results: All common kinds of SSRIs including fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and fluvoxamine were associated with lower HCC risk, and the findings were dose-dependent (eg, fluoxetine: 1-28 DDD [defined daily dose]: adjusted odds ratio [aOR]: 0.81, 95% confidence interval [CI], 0.73-0.89; 29-365 DDD: aOR: 0.71, 95% CI, 0.64-0.79; and ≥366 DDD: aOR: 0.55, 95% CI, 0.45-0.67) (P for trend <.001). Conclusions: All kinds of SSRIs were associated with decreased risk of HCC.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
Issue number1
Publication statusPublished - 2018 Jan


  • SSRIs
  • Taiwan national insurance
  • antidepressants
  • fluoxetine
  • hepatocellular carcinoma

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Oncology
  • Psychiatry and Mental health


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