Simultaneous determination of triclosan, triclocarban, and transformation products of triclocarban in aqueous samples using solid-phase micro-extraction-HPLC-MS/MS

Jermiah Y. Shen, Matt S. Chang, Sheng Hsiung Yang, Gaston J. C. Wu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The presence of triclosan and triclocarban, two endocrine-disrupting chemicals and antimicrobial agents, and transformation products of triclocarban, 1,3-di(phenyl)urea, 1,3-bis(4-chlorophenyl)urea and 1,3-bis(3,4-dichlorophenyl) urea, in tap water, treated household drinking water, bottled water, and river water samples were investigated using solid-phase micro-extraction coupled with-HPLC-MS/MS, a rapid, green, and sensitive method. Factors influencing the quantity of the analytes extracted onto the solid-phase micro-extraction fiber, such as addition of salt, sample pH, extraction time, desorption time, and sample volume, were optimized using solid-phase micro-extraction-HPLC-MS/MS. The results showed that the method gave satisfactory sensitivities and precisions for analyzing sub-part-per-trillion levels of triclosan, triclocarban, and transformation products of triclocarban in samples collected locally. The recoveries of analytes ranged from 97 to 107% for deionized water samples, and 99 to 110% for river water samples, and limits of detection were in the range of 0.32-3.44 and 0.38-4.67 ng/L for deionized water and river water samples, respectively. On average, the daily consumption of triclosan and triclocarban by an adult by consuming 2 liters of different types of drinking water were estimated to be in the range of 6.13-425 ng/day as a result of the concentrations of triclosan and triclocarban measured in this study.

Original languageEnglish
Pages (from-to)2544-2552
Number of pages9
JournalJournal of Separation Science
Volume35
Issue number19
DOIs
Publication statusPublished - 2012 Oct 1

Fingerprint

Triclosan
Urea
Drinking Water
Deionized water
Rivers
Water
Potable water
Antimicrobial agents
Endocrine Disruptors
Anti-Infective Agents
Desorption
triclocarban
Salts
Recovery
Fibers

Keywords

  • Antimicrobial agent
  • Endocrine disrupting chemicals
  • Solid phase micro-extraction
  • Triclocarban
  • Triclosan

ASJC Scopus subject areas

  • Analytical Chemistry
  • Filtration and Separation

Cite this

Simultaneous determination of triclosan, triclocarban, and transformation products of triclocarban in aqueous samples using solid-phase micro-extraction-HPLC-MS/MS. / Shen, Jermiah Y.; Chang, Matt S.; Yang, Sheng Hsiung; Wu, Gaston J. C.

In: Journal of Separation Science, Vol. 35, No. 19, 01.10.2012, p. 2544-2552.

Research output: Contribution to journalArticle

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abstract = "The presence of triclosan and triclocarban, two endocrine-disrupting chemicals and antimicrobial agents, and transformation products of triclocarban, 1,3-di(phenyl)urea, 1,3-bis(4-chlorophenyl)urea and 1,3-bis(3,4-dichlorophenyl) urea, in tap water, treated household drinking water, bottled water, and river water samples were investigated using solid-phase micro-extraction coupled with-HPLC-MS/MS, a rapid, green, and sensitive method. Factors influencing the quantity of the analytes extracted onto the solid-phase micro-extraction fiber, such as addition of salt, sample pH, extraction time, desorption time, and sample volume, were optimized using solid-phase micro-extraction-HPLC-MS/MS. The results showed that the method gave satisfactory sensitivities and precisions for analyzing sub-part-per-trillion levels of triclosan, triclocarban, and transformation products of triclocarban in samples collected locally. The recoveries of analytes ranged from 97 to 107{\%} for deionized water samples, and 99 to 110{\%} for river water samples, and limits of detection were in the range of 0.32-3.44 and 0.38-4.67 ng/L for deionized water and river water samples, respectively. On average, the daily consumption of triclosan and triclocarban by an adult by consuming 2 liters of different types of drinking water were estimated to be in the range of 6.13-425 ng/day as a result of the concentrations of triclosan and triclocarban measured in this study.",
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