TY - JOUR
T1 - Simple and sensitive determination of citrinin in Monascus by GC-selected ion monitoring mass spectrometry
AU - Shu, Pin Yen
AU - Lin, Cheng Huang
PY - 2002
Y1 - 2002
N2 - A new method for the qualitative and quantitative analysis of citrinin in Monascus by gas-chromatography-selected ion monitoring (SIM) mass spectrometry has been developed. GC separation of citrinin in Monascus extract was achieved without the need for chemical derivatization, and could be detected as a single peak when the SIM mode selected 5 prominent fragmentations (m/z of 220, 205, 177, 105 and 91). The quantitative detection limit for citrinin was ∼1 ppb. Finally, the GC-separated analyte from Monascus extract, at a retention time of 10.89 min, was examined by the method of pattern recognition by comparison with a citrinin standard. The results show that the 2 compounds had a 94% similarity when the SIM mode was used.
AB - A new method for the qualitative and quantitative analysis of citrinin in Monascus by gas-chromatography-selected ion monitoring (SIM) mass spectrometry has been developed. GC separation of citrinin in Monascus extract was achieved without the need for chemical derivatization, and could be detected as a single peak when the SIM mode selected 5 prominent fragmentations (m/z of 220, 205, 177, 105 and 91). The quantitative detection limit for citrinin was ∼1 ppb. Finally, the GC-separated analyte from Monascus extract, at a retention time of 10.89 min, was examined by the method of pattern recognition by comparison with a citrinin standard. The results show that the 2 compounds had a 94% similarity when the SIM mode was used.
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U2 - 10.2116/analsci.18.283
DO - 10.2116/analsci.18.283
M3 - Article
C2 - 11918186
AN - SCOPUS:0036228423
VL - 18
SP - 283
EP - 287
JO - Analytical Sciences
JF - Analytical Sciences
SN - 0910-6340
IS - 3
ER -