Silver-nanoparticle-conjugated polypeptide brushes for surface-enhanced raman scattering

Di Yan Wang, Tzu Shen Teng, Yi Chou Wu, Yi Cheng Lee, Kuei Hsien Chen, Chung Hsuan Chen, Ying Chih Chang, Chia Chun Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


A soft surface-enhanced Raman scattering (SERS) substrate was fabricated based on a three-dimensional (3D) structure of biocompatible end-tethered poly(L-lysine) ("t-PLL") with a brushlike configuration conjugated with silver nanoparticles (Ag NPs) (Ag NP-t-PLL film). The conjugation procedures were carefully adjusted to generate the films with different interval widths (W) between Ag NPs and diameters (D) of Ag NPs. The resulting film was then characterized by zeta potential, CD spectropolarimeter, and scanning electron microscopy. Furthermore, the studies of SERS enhancements using Ag NP-t-PLL film as a substrate were performed. The significant increases of SERS enhancements have been obtained as W/D was decreased from 0.9 to 0.2. Our results not only afford a facile fabrication of a 3D soft substrate for SERS with high sensitivity and biocompatibility but also offer great potentials for the development of new biosensors.

Original languageEnglish
Pages (from-to)13498-13504
Number of pages7
JournalJournal of Physical Chemistry C
Issue number31
Publication statusPublished - 2009 Aug 6

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Energy
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films


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