Silica gel-mediated friedel-crafts reaction of indoles with functionalized nitroallylic acetates via an SN1 process

Ching Yin Ho, Suparna Roy, Yan Ming Chen, Kwunmin Chen

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An environmentally friendly Friedel-Crafts reaction was demonstrated between indoles and functionalized nitroallylic acetates in the presence of silica gel, providing the corresponding C-3-selective regioisomers in good to high overall chemical yields (70-93%).

Original languageEnglish
Pages (from-to)940-946
Number of pages7
JournalJournal of the Chinese Chemical Society
Issue number8
Publication statusPublished - 2012 Aug 1



  • Electrophile
  • Friedel-Crafts reaction
  • Indole
  • Nitroallylic acetate
  • S 1

ASJC Scopus subject areas

  • Chemistry(all)

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