Signal analysis and liver tumor discrimination by using a high-Tc SQUID-based low-field NMR system in hospital

Shu Hsien Liao; Jen Jie Chieh; Yen Ting Chou; Ming Wei Wang; Hsin Hsien Chen; Kai Wen Huang; Hong Chang Yang; Herng Er Horng

doi:10.1109/TASC.2015.2393633

Signal analysis and liver tumor discrimination by using a high-T_c SQUID-based low-field NMR system in hospital

Shu Hsien Liao, Jen Jie Chieh, Yen Ting Chou, Ming Wei Wang, Hsin Hsien Chen, Kai Wen Huang, Hong Chang Yang, Herng Er Horng

Research output: Contribution to journal › Article › peer-review

Abstract

In this paper, a high-T_c SQUID-based nuclear magnetic resonance (NMR) spectrometer was set up in National Taiwan University Hospital to discriminate liver tumor. In order to overcome the surrounding noise, a four-layer Al shielded box and a cylindrical magnetic shield were employed to avoid the electromagnetic noise in the coils part and the SQUID part, respectively. For NMR measurement, the larmor frequency is varying with time due to the variation of static field in hospital. Therefore, the time-domain frequency adjusted average method guided by a fluxgate was used to correct the frequency variation and average the NMR signal in the time domain. For tumor discrimination, the T₁ relaxation times of normal tissue and tumor tissue were demonstrated. Our high-T_c SQUID-based low-field MRI system shows the feasibility for biomedical application in a clinic environment.

Original language	English
Article number	7012140
Journal	IEEE Transactions on Applied Superconductivity
Volume	25
Issue number	3
DOIs	https://doi.org/10.1109/TASC.2015.2393633
Publication status	Published - 2015 Jun 1

Keywords

SQUID
Ultra-low-field NMR
liver tumor

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

Access to Document

10.1109/TASC.2015.2393633

Cite this

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title = "Signal analysis and liver tumor discrimination by using a high-Tc SQUID-based low-field NMR system in hospital",

abstract = "In this paper, a high-Tc SQUID-based nuclear magnetic resonance (NMR) spectrometer was set up in National Taiwan University Hospital to discriminate liver tumor. In order to overcome the surrounding noise, a four-layer Al shielded box and a cylindrical magnetic shield were employed to avoid the electromagnetic noise in the coils part and the SQUID part, respectively. For NMR measurement, the larmor frequency is varying with time due to the variation of static field in hospital. Therefore, the time-domain frequency adjusted average method guided by a fluxgate was used to correct the frequency variation and average the NMR signal in the time domain. For tumor discrimination, the T1 relaxation times of normal tissue and tumor tissue were demonstrated. Our high-Tc SQUID-based low-field MRI system shows the feasibility for biomedical application in a clinic environment.",

keywords = "SQUID, Ultra-low-field NMR, liver tumor",

author = "Liao, {Shu Hsien} and Chieh, {Jen Jie} and Chou, {Yen Ting} and Wang, {Ming Wei} and Chen, {Hsin Hsien} and Huang, {Kai Wen} and Yang, {Hong Chang} and Horng, {Herng Er}",

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AU - Liao, Shu Hsien

AU - Chieh, Jen Jie

AU - Chou, Yen Ting

AU - Wang, Ming Wei

AU - Chen, Hsin Hsien

AU - Huang, Kai Wen

AU - Yang, Hong Chang

AU - Horng, Herng Er

PY - 2015/6/1

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N2 - In this paper, a high-Tc SQUID-based nuclear magnetic resonance (NMR) spectrometer was set up in National Taiwan University Hospital to discriminate liver tumor. In order to overcome the surrounding noise, a four-layer Al shielded box and a cylindrical magnetic shield were employed to avoid the electromagnetic noise in the coils part and the SQUID part, respectively. For NMR measurement, the larmor frequency is varying with time due to the variation of static field in hospital. Therefore, the time-domain frequency adjusted average method guided by a fluxgate was used to correct the frequency variation and average the NMR signal in the time domain. For tumor discrimination, the T1 relaxation times of normal tissue and tumor tissue were demonstrated. Our high-Tc SQUID-based low-field MRI system shows the feasibility for biomedical application in a clinic environment.

AB - In this paper, a high-Tc SQUID-based nuclear magnetic resonance (NMR) spectrometer was set up in National Taiwan University Hospital to discriminate liver tumor. In order to overcome the surrounding noise, a four-layer Al shielded box and a cylindrical magnetic shield were employed to avoid the electromagnetic noise in the coils part and the SQUID part, respectively. For NMR measurement, the larmor frequency is varying with time due to the variation of static field in hospital. Therefore, the time-domain frequency adjusted average method guided by a fluxgate was used to correct the frequency variation and average the NMR signal in the time domain. For tumor discrimination, the T1 relaxation times of normal tissue and tumor tissue were demonstrated. Our high-Tc SQUID-based low-field MRI system shows the feasibility for biomedical application in a clinic environment.

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KW - Ultra-low-field NMR

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