Semiautomatic and rapid quantification of heartbeat parameters in Drosophila using optical coherence tomography imaging

Shou Yuan Guo, Fang Tsu Liao, Ming-Tsan Su, Cheng Yi Chang, Hong Ren Su, Jyun Cin Huang, Wen Chuan Kuo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We report a semiautomatic algorithm that is specialized for rapid analysis of beat-to-beat contraction relaxation parameters of the heart in Drosophila. The presented algorithm adapts the general graph theoretical image segmentation algorithm and a histogram-based thresholding algorithm, which can measure many cardiac parameters, including heart rate, heart period, diastolic and systolic intervals, and end-diastolic and end-systolic areas. Additionally, dynamic cardiac functions, such as arrhythmia index and percent fractional shortening, can be automatically calculated for all the recorded heartbeats over significant periods of time.

Original languageEnglish
Article number026004
JournalJournal of Biomedical Optics
Volume18
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

Fingerprint

Drosophila
Optical tomography
tomography
Imaging techniques
synchronism
arrhythmia
heart rate
Image segmentation
histograms
contraction
intervals

Keywords

  • Cardiac function
  • Drosophila
  • Optical coherence tomography
  • Random walker algorithm

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Semiautomatic and rapid quantification of heartbeat parameters in Drosophila using optical coherence tomography imaging. / Guo, Shou Yuan; Liao, Fang Tsu; Su, Ming-Tsan; Chang, Cheng Yi; Su, Hong Ren; Huang, Jyun Cin; Kuo, Wen Chuan.

In: Journal of Biomedical Optics, Vol. 18, No. 2, 026004, 01.02.2013.

Research output: Contribution to journalArticle

Guo, Shou Yuan ; Liao, Fang Tsu ; Su, Ming-Tsan ; Chang, Cheng Yi ; Su, Hong Ren ; Huang, Jyun Cin ; Kuo, Wen Chuan. / Semiautomatic and rapid quantification of heartbeat parameters in Drosophila using optical coherence tomography imaging. In: Journal of Biomedical Optics. 2013 ; Vol. 18, No. 2.
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