Abstract
A Selectfluor and base mediated protocol for the synthesis of cyclohexanone ring fused isoxazole derivatives from isoxazoline N-oxides has been successfully developed. This rapid, one-pot, two-step transformation is achieved in acetonitrile, through nitroso intermediate followed by hydration, defluorination and N-O coupling in the presence of triethylamine. The scope and mechanism of the protocol have been demonstrated.
Original language | English |
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Pages (from-to) | 7505-7510 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 70 |
Issue number | 41 |
DOIs | |
Publication status | Published - 2014 Oct 14 |
Keywords
- Defluorination
- Heterocycles
- N-O coupling
- Synthetic methods
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry