TY - JOUR
T1 - Scaling Characteristics of the Magnetization Increments of Functionalized Nanoparticles Determined Using a Vibrating Sample Magnetometer for Liquid Magnetic Immunoassays
AU - Liao, Shu Hsien
AU - Huang, Han Sheng
AU - Su, Yu Kai
N1 - Funding Information:
Manuscript received January 25, 2018; revised April 6, 2018; accepted April 7, 2018. Date of publication April 13, 2018; date of current version September 18, 2019. This work was supported in part by the Ministry of Science and Technology of Taiwan under Grant 105-2112-M-003-012 and Grant 106-2112-M-003-002 and in part by the Aim for the Top University Plan of National Taiwan Normal University and the Ministry of Education, Taiwan, China, under Grant 104J1A27 and Grant 105J1A27. The associate editor coordinating the review of this paper and approving it for publication was Dr. Hadi Heidari. (Corresponding author: Shu-Hsien Liao.) The authors are with the Institute of Electro-Optical Science and Technology, National Taiwan Normal University, Taipei 116, Taiwan (e-mail: shliao@ntnu.edu.tw; hansheng9527@gmail.com; a20296111@gmail.com). Digital Object Identifier 10.1109/JSEN.2018.2825476
Publisher Copyright:
© 2001-2012 IEEE.
PY - 2019/10/15
Y1 - 2019/10/15
N2 - Here, scaling the normalized increment of dc magnetic susceptibility (Δ χ /χ) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (Δ M) after binding the C-reactive protein (CRP) to Fe3O4-anti-CRP. The results show that Δ M increased when the concentration of CRP increased. There was enhanced Δ M generated from magnetic clusters composed of Fe3O4-anti-CRP-CRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.
AB - Here, scaling the normalized increment of dc magnetic susceptibility (Δ χ /χ) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (Δ M) after binding the C-reactive protein (CRP) to Fe3O4-anti-CRP. The results show that Δ M increased when the concentration of CRP increased. There was enhanced Δ M generated from magnetic clusters composed of Fe3O4-anti-CRP-CRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.
KW - Biofunctionalized magnetic nanoparticles
KW - C-reactive protein
KW - magnetic immunoassays
KW - vibrating sample magnetometers
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U2 - 10.1109/JSEN.2018.2825476
DO - 10.1109/JSEN.2018.2825476
M3 - Article
AN - SCOPUS:85045643502
SN - 1530-437X
VL - 19
SP - 8990
EP - 8994
JO - IEEE Sensors Journal
JF - IEEE Sensors Journal
IS - 20
M1 - 8337743
ER -