Scaling characteristics of the magnetization increments of functionalized nanoparticles determined using a vibrating sample magnetometer for liquid magnetic immunoassays

Shu Hsien Liao, Han Sheng Huang, Yu Kai Su

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Here, scaling the normalized increment of dc magnetic susceptibility (Δχq/χq) to a characteristic logistic function provides a foundation for characterizing unknown quantities of biomarkers. We report the scaling behavior of magnetization increments in reagents composed of biofunctionalized magnetic nanoparticles (BMNs) conjugated with biotargets for liquid magnetic immunoassays. We measured hysteresis loops and obtained the increment of magnetization (ΔM) after binding the C-reactive protein (CRP) to Fe3O4–Vanti-CRP. The results show that ΔM increased when the concentration of CRP increased. There was enhanced ΔM generated from magnetic clusters composed of Fe3O4–Vanti-CRP–VCRP. The present platform is robust, easy to use, and can be applied to assays for various biomolecules for tumor markers, viruses, and proteins.

Original languageEnglish
Article number8337743
Pages (from-to)8990-8994
Number of pages5
JournalIEEE Sensors Journal
Volume19
Issue number20
DOIs
Publication statusAccepted/In press - 2018 Apr 12

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Keywords

  • biofunctionalized magnetic nanoparticles
  • C-reactive protein
  • Magnetic hysteresis
  • magnetic immunoassays
  • Magnetic resonance imaging
  • Magnetic susceptibility
  • Magnetization
  • Magnetometers
  • Saturation magnetization
  • Superconducting magnets
  • vibrating sample magnetometers

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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