Role of High Mobility Group Box 1 (HMGB1) in SCA17 pathogenesis

Medicine & Life Sciences

• Spinocerebellar Ataxia 17 100%
• TATA-Box Binding Protein 76%
• polyglutamine 17%
• Mutant Proteins 14%
• Autophagy 12%
• Starvation 9%
• General Transcription Factors 6%
• Peptide Initiation Factors 5%
• Protein Aggregates 5%
• Protein Binding 4%
• Drug Development 4%
• Luciferases 4%
• Proteomics 4%
• Transfection 3%
• Small Interfering RNA 3%
• Complementary DNA 3%
• Reactive Oxygen Species 3%
• Proteins 3%
• Pathology 2%
• Gene Expression 2%

Agriculture & Biology

• pathogenesis 48%
• binding proteins 45%
• autophagy 15%
• cells 11%
• starvation 7%
• mutants 7%
• transcription initiation 5%
• drug development 5%
• small interfering RNA 5%
• luciferase 4%
• transfection 4%
• protein aggregates 4%
• proteomics 3%
• reactive oxygen species 3%
• transcription (genetics) 3%
• proteins 2%
• gene expression 2%
• assays 2%

Chemical Compounds

• Compound Mobility 40%
• Protein 21%
• Silencing RNA 5%
• Complementary DNA 4%
• Reactive Oxygen Metabolite 3%
• Reduction 3%
• Drug 2%