Risk of prostate and bladder cancers in patients with spinal cord injury: A population-based cohort study1

Wen Yuan Lee, Li Min Sun, Cheng Li Lin, Ji An Liang, Yen Jung Chang, Fung Chang Sung, Chia Hung Kao

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To evaluate the risk of prostate and bladder cancers in patients with spinal cord injury (SCI). Materials and methods: We used data obtained from the National Health Insurance system of Taiwan for this study. The SCI cohort contained 54,401 patients with SCI, and each patient was randomly frequency matched with 4 people from the general population (without SCI) based on age, sex, and index date. Incidence rates, SCI cohort to non-SCI cohort rate ratios, and hazard ratios were measured to evaluate the cancer risks. Results: Patients with SCI showed a significantly lower risk of developing prostate cancer compared with subjects without SCI (adjusted hazard ratio = 0.73; 95% confidence interval = 0.59, 0.90), after accounting for the competing risk of death. No significant difference in the risk of bladder cancer emerged between the SCI and control groups. Further analyses found a higher spinal level of SCI tended to predict a lower risk for prostate cancer. Conclusions: Patients with SCI incurred a lower risk for prostate cancer compared with people without SCI. The risk for bladder cancer did not differ between people with or without SCI.

Original languageEnglish
Pages (from-to)51.e1-51.e7
JournalUrologic Oncology: Seminars and Original Investigations
Volume32
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • Bladder cancer
  • Cohort study
  • Prostate cancer
  • Spinal cord injury

ASJC Scopus subject areas

  • Oncology
  • Urology

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