Risk of Dementia in First-Degree Relatives of Patients with Alzheimer's Disease and Related Disorders

Mary Sano, Jenn Chen, Thomas Tatemichi, Yaakov Stern, Richard Mayeux

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

First-degree relatives of patients with Alzheimer's disease (AD) are at greater risk for dementia when compared with the relatives of their healthy peers, but not when compared with the relatives of patients with Parkinson's disease. This may indicate that the risk of dementia in these relatives is not specific to AD or that these studies are biased. We obtained a family history and vital status information on each first-degree relative of patients attending a clinic and in a group of recruited healthy elderly subjects. Patients formed two groups: probable AD and other forms of dementia or cognitive disorders without dementia. The odds of dementia in first-degree relatives did not differ between patient groups. The odds of dementia in relatives of patients with probable AD or other forms of dementia was six times that in the relatives of the healthy elderly subjects. The cumulative incidence of dementia increased with age in the first-degree relatives of all subjects. Approximately 50% of the first-degree relatives of patients with AD were demented by age 91 years, but almost the same number of the other patient group's relatives were demented as well. That figure was never reached in the healthy elderly subject's relatives. Because the risk of dementia in first-degree relatives of patients with AD was similar to that for patients with other disorders, we cannot exclude the possibility that this is the result of selection and information biases. Our investigation implies that the increased risk of dementia may not be specific to relatives of patients with AD; the risk may also be increased in first-degree relatives of patients with other neurologic disorders.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalArchives of Neurology
Volume48
Issue number3
DOIs
Publication statusPublished - 1991 Mar

Fingerprint

Dementia
Alzheimer Disease
Healthy Volunteers
Alzheimer's Disease
Selection Bias
Nervous System Diseases
Parkinson Disease

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Risk of Dementia in First-Degree Relatives of Patients with Alzheimer's Disease and Related Disorders. / Sano, Mary; Chen, Jenn; Tatemichi, Thomas; Stern, Yaakov; Mayeux, Richard.

In: Archives of Neurology, Vol. 48, No. 3, 03.1991, p. 269-273.

Research output: Contribution to journalArticle

Sano, Mary ; Chen, Jenn ; Tatemichi, Thomas ; Stern, Yaakov ; Mayeux, Richard. / Risk of Dementia in First-Degree Relatives of Patients with Alzheimer's Disease and Related Disorders. In: Archives of Neurology. 1991 ; Vol. 48, No. 3. pp. 269-273.
@article{72b04fcebaa6496c80489f6b9df2be2b,
title = "Risk of Dementia in First-Degree Relatives of Patients with Alzheimer's Disease and Related Disorders",
abstract = "First-degree relatives of patients with Alzheimer's disease (AD) are at greater risk for dementia when compared with the relatives of their healthy peers, but not when compared with the relatives of patients with Parkinson's disease. This may indicate that the risk of dementia in these relatives is not specific to AD or that these studies are biased. We obtained a family history and vital status information on each first-degree relative of patients attending a clinic and in a group of recruited healthy elderly subjects. Patients formed two groups: probable AD and other forms of dementia or cognitive disorders without dementia. The odds of dementia in first-degree relatives did not differ between patient groups. The odds of dementia in relatives of patients with probable AD or other forms of dementia was six times that in the relatives of the healthy elderly subjects. The cumulative incidence of dementia increased with age in the first-degree relatives of all subjects. Approximately 50{\%} of the first-degree relatives of patients with AD were demented by age 91 years, but almost the same number of the other patient group's relatives were demented as well. That figure was never reached in the healthy elderly subject's relatives. Because the risk of dementia in first-degree relatives of patients with AD was similar to that for patients with other disorders, we cannot exclude the possibility that this is the result of selection and information biases. Our investigation implies that the increased risk of dementia may not be specific to relatives of patients with AD; the risk may also be increased in first-degree relatives of patients with other neurologic disorders.",
author = "Mary Sano and Jenn Chen and Thomas Tatemichi and Yaakov Stern and Richard Mayeux",
year = "1991",
month = "3",
doi = "10.1001/archneur.1991.00530150037014",
language = "English",
volume = "48",
pages = "269--273",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "3",

}

TY - JOUR

T1 - Risk of Dementia in First-Degree Relatives of Patients with Alzheimer's Disease and Related Disorders

AU - Sano, Mary

AU - Chen, Jenn

AU - Tatemichi, Thomas

AU - Stern, Yaakov

AU - Mayeux, Richard

PY - 1991/3

Y1 - 1991/3

N2 - First-degree relatives of patients with Alzheimer's disease (AD) are at greater risk for dementia when compared with the relatives of their healthy peers, but not when compared with the relatives of patients with Parkinson's disease. This may indicate that the risk of dementia in these relatives is not specific to AD or that these studies are biased. We obtained a family history and vital status information on each first-degree relative of patients attending a clinic and in a group of recruited healthy elderly subjects. Patients formed two groups: probable AD and other forms of dementia or cognitive disorders without dementia. The odds of dementia in first-degree relatives did not differ between patient groups. The odds of dementia in relatives of patients with probable AD or other forms of dementia was six times that in the relatives of the healthy elderly subjects. The cumulative incidence of dementia increased with age in the first-degree relatives of all subjects. Approximately 50% of the first-degree relatives of patients with AD were demented by age 91 years, but almost the same number of the other patient group's relatives were demented as well. That figure was never reached in the healthy elderly subject's relatives. Because the risk of dementia in first-degree relatives of patients with AD was similar to that for patients with other disorders, we cannot exclude the possibility that this is the result of selection and information biases. Our investigation implies that the increased risk of dementia may not be specific to relatives of patients with AD; the risk may also be increased in first-degree relatives of patients with other neurologic disorders.

AB - First-degree relatives of patients with Alzheimer's disease (AD) are at greater risk for dementia when compared with the relatives of their healthy peers, but not when compared with the relatives of patients with Parkinson's disease. This may indicate that the risk of dementia in these relatives is not specific to AD or that these studies are biased. We obtained a family history and vital status information on each first-degree relative of patients attending a clinic and in a group of recruited healthy elderly subjects. Patients formed two groups: probable AD and other forms of dementia or cognitive disorders without dementia. The odds of dementia in first-degree relatives did not differ between patient groups. The odds of dementia in relatives of patients with probable AD or other forms of dementia was six times that in the relatives of the healthy elderly subjects. The cumulative incidence of dementia increased with age in the first-degree relatives of all subjects. Approximately 50% of the first-degree relatives of patients with AD were demented by age 91 years, but almost the same number of the other patient group's relatives were demented as well. That figure was never reached in the healthy elderly subject's relatives. Because the risk of dementia in first-degree relatives of patients with AD was similar to that for patients with other disorders, we cannot exclude the possibility that this is the result of selection and information biases. Our investigation implies that the increased risk of dementia may not be specific to relatives of patients with AD; the risk may also be increased in first-degree relatives of patients with other neurologic disorders.

UR - http://www.scopus.com/inward/record.url?scp=0025978557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025978557&partnerID=8YFLogxK

U2 - 10.1001/archneur.1991.00530150037014

DO - 10.1001/archneur.1991.00530150037014

M3 - Article

C2 - 2001183

AN - SCOPUS:0025978557

VL - 48

SP - 269

EP - 273

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 3

ER -