TY - JOUR
T1 - Risk of ADHD After Multiple Exposures to General Anesthesia
T2 - A Nationwide Retrospective Cohort Study
AU - Tsai, Chia Jui
AU - Lee, Charles Tzu Chi
AU - Liang, Sophie Hsin Yi
AU - Tsai, Pei Jung
AU - Chen, Vincent Chin Hung
AU - Gossop, Michael
N1 - Publisher Copyright:
© 2015, © The Author(s) 2015.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Objective: To study the association between general anesthesia exposure before age 3 years and having a later ADHD diagnosis. Method: In a birth cohort, data were collected from a nationwide population database for children born between 1997 and 1999 who were exposed to general anesthesia before their third birthday. Age- and gender-matched enrollees without general anesthesia exposure were taken as the comparison. Groups were compared to identify the incidence of ADHD after age 4 and anesthesia-related predictive factors. Results: Among the 1,146 exposed children, 74 ADHD cases were identified, and 158 ADHD cases were identified in 3,438 matched controls. After adjusting for comorbid conditions and possible confounding factors, if exposure on more than one occasion or ≥3 hr, an increased likelihood of having a later ADHD diagnosis was found (HR, 1.71 and 2.43, respectively). Conclusion: Children with multiple or ≥3 hr general anesthesia exposures before age 3 years have an increased likelihood of a later ADHD diagnosis.
AB - Objective: To study the association between general anesthesia exposure before age 3 years and having a later ADHD diagnosis. Method: In a birth cohort, data were collected from a nationwide population database for children born between 1997 and 1999 who were exposed to general anesthesia before their third birthday. Age- and gender-matched enrollees without general anesthesia exposure were taken as the comparison. Groups were compared to identify the incidence of ADHD after age 4 and anesthesia-related predictive factors. Results: Among the 1,146 exposed children, 74 ADHD cases were identified, and 158 ADHD cases were identified in 3,438 matched controls. After adjusting for comorbid conditions and possible confounding factors, if exposure on more than one occasion or ≥3 hr, an increased likelihood of having a later ADHD diagnosis was found (HR, 1.71 and 2.43, respectively). Conclusion: Children with multiple or ≥3 hr general anesthesia exposures before age 3 years have an increased likelihood of a later ADHD diagnosis.
KW - ADHD
KW - NHIRD
KW - general anesthesia
KW - risk
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U2 - 10.1177/1087054715587094
DO - 10.1177/1087054715587094
M3 - Article
C2 - 26023173
AN - SCOPUS:85040659875
SN - 1087-0547
VL - 22
SP - 229
EP - 239
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 3
ER -