Resveratrol induces expression of metabolic and antioxidant machinery and protects tilapia under cold stress

Min Chen Wang, Yu Chun Wang, Hui Wen Peng, Jinn Rong Hseu, Guan Chung Wu, Ching Fong Chang, Yung Che Tseng*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Exposures to low ambient temperature require ectothermic fish to not only adjust their metabolic machinery but also to mount protective responses against oxidative stress. In this study, we tested whether diets supplemented with resveratrol (RSV), a naturally occurring polyphenol known to stimulate metabolic and protective responses in various animals, would be beneficial to tilapia (Oreochromis mossambicus) under hypothermic challenge. Feeding tilapia with RSV-supplemented diet promoted liver expression of sirtuins and their known targets, including metabolic/antioxidative enzymes. After exposure to 15 C cold conditions for three days, the oxygen–nitrogen (O:N) ratio was decreased in the control-diet-fed tilapia but not in their RSV-fed counterparts. Moreover, at 27 C, RSV-fed tilapia showed significantly higher prolonged swim speed compared with controls. RSV feeding produced no significant effect on upper and bottom layer preference between the control-and RSV-treated tilapia at either 27 C or 15 C. Together, these findings suggest that RSV stimulates beneficial metabolic/antioxidative adjustments in teleosts and may serve as a valuable feed supplement for tropical fish exposed to cold stress during winter.

Original languageEnglish
Article number3338
JournalInternational journal of molecular sciences
Issue number9
Publication statusPublished - 2020 May 1
Externally publishedYes


  • Antioxidation
  • Low temperature
  • Metabolic adjustment
  • Resveratrol
  • Sirtuin
  • Tilapia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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