Abstract
L-carnitine L-tartrate (LCLT) supplementation beneficially affects markers of postexercise metabolic stress and muscle damage. However, to date, no study has determined the dose response of LCLT to elicit such responses. Therefore, the purpose of this study was to determine the effects of different doses of LCLT on criterion variables previously shown to be responsive to LCLT supplementation. Eight healthy men (22 ± 3 y, 174 ± 5 cm, 83.0 ± 15.3 kg) were supplemented with 0 g, 1 g, and 2 g of LCLT for 3 weeks and then performed a bout of resistance exercise (5 sets of 15-20 repetition maximum with a 2-min rest between sets) with associated blood draws. This procedure was performed in a balanced, randomized, repeated measures design. Serum carnitine concentrations increased (p ≤ 0.05) following the 1 g and 2 g doses, with the 2-g dose providing the highest carnitine concentrations. The 1-and 2-g doses reduced postexercise serum hypoxanthine, serum xanthine oxidase, serum myoglobin, and perceived muscle soreness. In conclusion, both the 1- and 2-g doses were effective in mediating various markers of metabolic stress and of muscle soreness. Use of LCLT appears to attenuate metabolic stress and the hypoxic chain of events leading to muscle damage after exercise.
| Original language | English |
|---|---|
| Pages (from-to) | 259-264 |
| Number of pages | 6 |
| Journal | Journal of Strength and Conditioning Research |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 Jan 1 |
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Keywords
- Ergogenic aids
- Metabolic stress
- Performance
- Recovery
- Sports supplements
- Strength training
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation
Cite this
Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate. / Spiering, Barry A.; Kraemer, William J.; Vingren, Jakob L.; Hatfield, Disa L.; Fragala, Maren S.; Ho, Jen-Yu; Maresh, Carl M.; Anderson, Jeffrey M.; Volek, Jeff S.
In: Journal of Strength and Conditioning Research, Vol. 21, No. 1, 01.01.2007, p. 259-264.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Responses of criterion variables to different supplemental doses of L-carnitine L-tartrate
AU - Spiering, Barry A.
AU - Kraemer, William J.
AU - Vingren, Jakob L.
AU - Hatfield, Disa L.
AU - Fragala, Maren S.
AU - Ho, Jen-Yu
AU - Maresh, Carl M.
AU - Anderson, Jeffrey M.
AU - Volek, Jeff S.
PY - 2007/1/1
Y1 - 2007/1/1
N2 - L-carnitine L-tartrate (LCLT) supplementation beneficially affects markers of postexercise metabolic stress and muscle damage. However, to date, no study has determined the dose response of LCLT to elicit such responses. Therefore, the purpose of this study was to determine the effects of different doses of LCLT on criterion variables previously shown to be responsive to LCLT supplementation. Eight healthy men (22 ± 3 y, 174 ± 5 cm, 83.0 ± 15.3 kg) were supplemented with 0 g, 1 g, and 2 g of LCLT for 3 weeks and then performed a bout of resistance exercise (5 sets of 15-20 repetition maximum with a 2-min rest between sets) with associated blood draws. This procedure was performed in a balanced, randomized, repeated measures design. Serum carnitine concentrations increased (p ≤ 0.05) following the 1 g and 2 g doses, with the 2-g dose providing the highest carnitine concentrations. The 1-and 2-g doses reduced postexercise serum hypoxanthine, serum xanthine oxidase, serum myoglobin, and perceived muscle soreness. In conclusion, both the 1- and 2-g doses were effective in mediating various markers of metabolic stress and of muscle soreness. Use of LCLT appears to attenuate metabolic stress and the hypoxic chain of events leading to muscle damage after exercise.
AB - L-carnitine L-tartrate (LCLT) supplementation beneficially affects markers of postexercise metabolic stress and muscle damage. However, to date, no study has determined the dose response of LCLT to elicit such responses. Therefore, the purpose of this study was to determine the effects of different doses of LCLT on criterion variables previously shown to be responsive to LCLT supplementation. Eight healthy men (22 ± 3 y, 174 ± 5 cm, 83.0 ± 15.3 kg) were supplemented with 0 g, 1 g, and 2 g of LCLT for 3 weeks and then performed a bout of resistance exercise (5 sets of 15-20 repetition maximum with a 2-min rest between sets) with associated blood draws. This procedure was performed in a balanced, randomized, repeated measures design. Serum carnitine concentrations increased (p ≤ 0.05) following the 1 g and 2 g doses, with the 2-g dose providing the highest carnitine concentrations. The 1-and 2-g doses reduced postexercise serum hypoxanthine, serum xanthine oxidase, serum myoglobin, and perceived muscle soreness. In conclusion, both the 1- and 2-g doses were effective in mediating various markers of metabolic stress and of muscle soreness. Use of LCLT appears to attenuate metabolic stress and the hypoxic chain of events leading to muscle damage after exercise.
KW - Ergogenic aids
KW - Metabolic stress
KW - Performance
KW - Recovery
KW - Sports supplements
KW - Strength training
UR - http://www.scopus.com/inward/record.url?scp=33947680182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947680182&partnerID=8YFLogxK
U2 - 10.1519/00124278-200702000-00046
DO - 10.1519/00124278-200702000-00046
M3 - Article
C2 - 17313301
AN - SCOPUS:33947680182
VL - 21
SP - 259
EP - 264
JO - Journal of Strength and Conditioning Research
JF - Journal of Strength and Conditioning Research
SN - 1064-8011
IS - 1
ER -