Respiratory-Related Facial Nerve Activity in Response to Activation of the Rostral Ventrolateral Medulla in the Cat

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Abstract

The effects of electrical and chemical activation of the rostral ventrolateral medulla (rVLM) on respiratory-related facial nerve activity were investigated in decerebrated, paralyzed, vagotomized and ventilated cats. The animal was maintained at normocapnia and hypercapnia in hyperoxia. Phrenic and facial nerve activities were simultaneously recorded. Excitation of the rVLM either by electrical current (12.5 to 50 μA, 80 Hz and 0.5 ms pulse duration) or glutamate microinjection (50 mM, 20 to 200 nl) inhibited both phrenic and facial nerve discharges. Although inhibition of the rVLM upon both nerves was attenuated by hypercapnia, this inhibition remained significant during hypercapnia. These results suggest that the rVLM may be involved in the modulation of upper airway patency by controlling respiratory-related facial nerve activity.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalChinese Journal of Physiology
Volume40
Issue number2
Publication statusPublished - 1997 Jun 30

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Facial Nerve
Hypercapnia
Cats
Phrenic Nerve
Hyperoxia
Microinjections
Glutamic Acid

Keywords

  • Cat
  • Facial nerve
  • Phrenic nerve
  • Rostral ventrolateral medulla
  • Upper airway patency

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

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title = "Respiratory-Related Facial Nerve Activity in Response to Activation of the Rostral Ventrolateral Medulla in the Cat",
abstract = "The effects of electrical and chemical activation of the rostral ventrolateral medulla (rVLM) on respiratory-related facial nerve activity were investigated in decerebrated, paralyzed, vagotomized and ventilated cats. The animal was maintained at normocapnia and hypercapnia in hyperoxia. Phrenic and facial nerve activities were simultaneously recorded. Excitation of the rVLM either by electrical current (12.5 to 50 μA, 80 Hz and 0.5 ms pulse duration) or glutamate microinjection (50 mM, 20 to 200 nl) inhibited both phrenic and facial nerve discharges. Although inhibition of the rVLM upon both nerves was attenuated by hypercapnia, this inhibition remained significant during hypercapnia. These results suggest that the rVLM may be involved in the modulation of upper airway patency by controlling respiratory-related facial nerve activity.",
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N2 - The effects of electrical and chemical activation of the rostral ventrolateral medulla (rVLM) on respiratory-related facial nerve activity were investigated in decerebrated, paralyzed, vagotomized and ventilated cats. The animal was maintained at normocapnia and hypercapnia in hyperoxia. Phrenic and facial nerve activities were simultaneously recorded. Excitation of the rVLM either by electrical current (12.5 to 50 μA, 80 Hz and 0.5 ms pulse duration) or glutamate microinjection (50 mM, 20 to 200 nl) inhibited both phrenic and facial nerve discharges. Although inhibition of the rVLM upon both nerves was attenuated by hypercapnia, this inhibition remained significant during hypercapnia. These results suggest that the rVLM may be involved in the modulation of upper airway patency by controlling respiratory-related facial nerve activity.

AB - The effects of electrical and chemical activation of the rostral ventrolateral medulla (rVLM) on respiratory-related facial nerve activity were investigated in decerebrated, paralyzed, vagotomized and ventilated cats. The animal was maintained at normocapnia and hypercapnia in hyperoxia. Phrenic and facial nerve activities were simultaneously recorded. Excitation of the rVLM either by electrical current (12.5 to 50 μA, 80 Hz and 0.5 ms pulse duration) or glutamate microinjection (50 mM, 20 to 200 nl) inhibited both phrenic and facial nerve discharges. Although inhibition of the rVLM upon both nerves was attenuated by hypercapnia, this inhibition remained significant during hypercapnia. These results suggest that the rVLM may be involved in the modulation of upper airway patency by controlling respiratory-related facial nerve activity.

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KW - Facial nerve

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