Renal function of substance P in rats chronically exposed to hypoxia

Chau Fong Chen, Li Wen Chen, Chiang-Ting Chien, Ming Shiou Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: We studied the renal action of substance P (SP) in rats chronically exposed to hypoxia (high altitude, HA), compared to control rats kept at sea level (SL). Methods: Hypoxia was induced by placing female Wistar rats (182-225 g) in an altitude chamber (5500 m) 15 h · d-1 for 4 weeks. Results: Intrarenal arterial infusion of substance P (60 ng · kg-1 · h- 1) increased the excretion of urine, sodium in both groups of rats, however, the excretion of kallikrein (KK) and the glomerular filtration rate (GFR) were not significantly altered. After aprotinin (10,000 kiu · kg-1 · min-1) treatment, kallikrein was depleted and substance P lost its diuretic action. Spantide, an SP antagonist (6000 ng · kg-1 · h-1, I.V.) decreased urine, and urinary excretion of sodium and potassium in SL rats, but not in HA rats. Acute renal denervated diuresis in SL rats was not modified after Spantide administration. Finally, it was found that both SP and SP antagonist did not significantly change the renal parameters in either group of rats after chronic renal denervation. Conclusion: We made the following conclusions: a) endogenous renal action of SP was suggested in SL but not in HA rats; b) the renal action of SP might be through KK release, although urinary KK did not increase after SP administration; and c) SP action is renal nerve dependent in both groups of rats.

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalAviation Space and Environmental Medicine
Volume68
Issue number8
Publication statusPublished - 1997 Aug 1

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Substance P
Rats
Kidney
Sea level
Oceans and Seas
Tissue Kallikreins
Kallikreins
Sodium
Rat control
Hypoxia
Urine
Altitude Sickness
Aprotinin
Diuresis
Denervation
Glomerular Filtration Rate
Diuretics
Potassium
Wistar Rats

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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Renal function of substance P in rats chronically exposed to hypoxia. / Chen, Chau Fong; Chen, Li Wen; Chien, Chiang-Ting; Wu, Ming Shiou.

In: Aviation Space and Environmental Medicine, Vol. 68, No. 8, 01.08.1997, p. 705-709.

Research output: Contribution to journalArticle

Chen, Chau Fong ; Chen, Li Wen ; Chien, Chiang-Ting ; Wu, Ming Shiou. / Renal function of substance P in rats chronically exposed to hypoxia. In: Aviation Space and Environmental Medicine. 1997 ; Vol. 68, No. 8. pp. 705-709.
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