Removal of lipopolysaccharide and reactive Oxygen species using sialic acid immobilized polysulfone dialyzer

Jung Jhih Chang, Po Jub Lin, Ming Chien Yang, Chiang-Ting Chien

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4 Citations (Scopus)


Sialic acid (N-acetylneuraminic acid, NANA) was covalently immobilized onto the surface of a polysulfone (PSF) hollow fiber membrane. Prior to the immobilization, the surface of PSF was treated with ozone, followed by grafting with acrylic acid, and then the esterification of NANA. The surface concentration of NANA was determined by 2-thiobarbituric acid (TBA) test. Hemocompatibility, the capability of suppressing oxidative stress, and clearance of lipopolysaccharide (LPS) from the resulting hollow fiber membrane were evaluated. The results show that by immobilizing NANA onto PSF hollow fiber, the adhesion of platelet was reduced, while both APTT and PT were little affected. Furthermore, oxidative stress was suppressed by NANA-immobilized PSF hollow fibers. The level of LPS was also greatly reduced.

Original languageEnglish
Pages (from-to)871-877
Number of pages7
JournalPolymers for Advanced Technologies
Issue number12
Publication statusPublished - 2009 Dec 1



  • Blood compatibility
  • Lipopolysaccharide
  • Polysulfone
  • Reactive oxygen species (ROS)
  • Sialic acid

ASJC Scopus subject areas

  • Polymers and Plastics

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