Removal of lipopolysaccharide and reactive Oxygen species using sialic acid immobilized polysulfone dialyzer

Jung Jhih Chang, Po Jub Lin, Ming Chien Yang, Chiang-Ting Chien

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sialic acid (N-acetylneuraminic acid, NANA) was covalently immobilized onto the surface of a polysulfone (PSF) hollow fiber membrane. Prior to the immobilization, the surface of PSF was treated with ozone, followed by grafting with acrylic acid, and then the esterification of NANA. The surface concentration of NANA was determined by 2-thiobarbituric acid (TBA) test. Hemocompatibility, the capability of suppressing oxidative stress, and clearance of lipopolysaccharide (LPS) from the resulting hollow fiber membrane were evaluated. The results show that by immobilizing NANA onto PSF hollow fiber, the adhesion of platelet was reduced, while both APTT and PT were little affected. Furthermore, oxidative stress was suppressed by NANA-immobilized PSF hollow fibers. The level of LPS was also greatly reduced.

Original languageEnglish
Pages (from-to)871-877
Number of pages7
JournalPolymers for Advanced Technologies
Volume20
Issue number12
DOIs
Publication statusPublished - 2009 Dec 1

Fingerprint

Polysulfones
N-Acetylneuraminic Acid
Lipopolysaccharides
Reactive Oxygen Species
Oxygen
Acids
Oxidative stress
Fibers
Membranes
Ozone
Esterification
Platelets
polysulfone P 1700
Adhesion
Acrylics

Keywords

  • Blood compatibility
  • Lipopolysaccharide
  • Polysulfone
  • Reactive oxygen species (ROS)
  • Sialic acid

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Removal of lipopolysaccharide and reactive Oxygen species using sialic acid immobilized polysulfone dialyzer. / Chang, Jung Jhih; Lin, Po Jub; Yang, Ming Chien; Chien, Chiang-Ting.

In: Polymers for Advanced Technologies, Vol. 20, No. 12, 01.12.2009, p. 871-877.

Research output: Contribution to journalArticle

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