Remarkable reaction rate and excellent enantioselective direct α-amination of aldehydes with azodicarboxylates catalyzed by pyrrolidinylcamphor-derived organocatalysts

Pang Min Liu, Chihliang Chang, Raju Jannapu Reddy, Ying Fang Ting, Hsuan Hao Kuan, Kwunmin Chen

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34 Citations (Scopus)

Abstract

Remarkable reaction rate and excellent enantioselective direct α-amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organocatalyst 2a (5 mol-%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99%ee) at 0 °C in CH 2Cl2.

Original languageEnglish
Pages (from-to)42-46
Number of pages5
JournalEuropean Journal of Organic Chemistry
Issue number1
DOIs
Publication statusPublished - 2010 Jan 8

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Keywords

  • Amination
  • Asymmetric catalysis
  • Nitrogen heterocycles
  • Organocatalysis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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