Remarkable reaction rate and excellent enantioselective direct α-amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organocatalyst 2a (5 mol-%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99%ee) at 0 °C in CH 2Cl2.
- Asymmetric catalysis
- Nitrogen heterocycles
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry