Relaxation rates of protons in gadolinium chelates detected with a high-Tc superconducting quantum interference device in microtesla magnetic fields

Hsin Hsien Chen, Hong Chang Yang, Herng Er Horng, Jong Kai Hsiao, Shieh Yueh Yang, Shu Hsien Liao, Ming Jye Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A nuclear magnetic resonance and imaging system was constructed to study spin-lattice relaxation time T1, spin-spin relaxation time T 2, and effective relaxation time T2 of gadolinium (Gd) chelates using a high- Tc superconducting quantum interference device in microtesla magnetic fields. In the presence of the magnetic contrast T2 is related to T2 by the relation: 1/ T2 =1/ T2 +γΔB+ Gd-chelates, where γ=42.58 kHz/mT and γΔB is the relaxation rate due to the inhomogeneity field ΔB in measuring coil at the sample position and Gd-chelates is the intrinsic relaxation rate of Gd chelates. It is found that T1, T2, and 1/ Gd-chelates decay exponentially as the concentration (or magnetic susceptibility) of Gd chelates increases. The Gd chelates cause a diffusive motion of nuclear spins and hence enhance the relaxation rates. Enhanced image contrast has been demonstrated in a water phantom with Gd chelates in microtesla magnetic fields.

Original languageEnglish
Article number093904
JournalJournal of Applied Physics
Volume108
Issue number9
DOIs
Publication statusPublished - 2010 Nov 1

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Relaxation rates of protons in gadolinium chelates detected with a high-T<sub>c</sub> superconducting quantum interference device in microtesla magnetic fields'. Together they form a unique fingerprint.

  • Cite this