Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang; L. L. Chiu; S. H. Liao; H. H. Chen; H. E. Horng; C. W. Liu; C. I. Liu; K. L. Chen; M. J. Chen; L. M. Wang

doi:10.1063/1.4789009

Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang^*
, L. L. Chiu
, S. H. Liao
, H. H. Chen
, H. E. Horng
, C. W. Liu
, C. I. Liu
, K. L. Chen
, M. J. Chen
, L. M. Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this work, the spin-spin relaxation rate, 1/T₂, and spin-lattice relaxation rate, 1/T₁, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-T_c superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe₃O₄, which is labeled as Fe₃O₄-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T₂ and 1/T₁ of protons in Fe₃O₄-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T₁ and 1/T₂ of Fe₃O₄-antiCRP are close to that of ferrofluids, which are dextran-coated Fe₃O₄ dispersed in phosphate buffer saline. Characterizing the relaxation of Fe₃O₄-antiCRP can be useful for biomedical applications.

Original language	English
Article number	043911
Journal	Journal of Applied Physics
Volume	113
Issue number	4
DOIs	https://doi.org/10.1063/1.4789009
Publication status	Published - 2013 Jan 28

ASJC Scopus subject areas

General Physics and Astronomy

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10.1063/1.4789009

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@article{d30b789fb10d4ba3bd252e71ea9e339c,

title = "Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields",

abstract = "In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.",

author = "Yang, \{H. C.\} and Chiu, \{L. L.\} and Liao, \{S. H.\} and Chen, \{H. H.\} and Horng, \{H. E.\} and Liu, \{C. W.\} and Liu, \{C. I.\} and Chen, \{K. L.\} and Chen, \{M. J.\} and Wang, \{L. M.\}",

note = "Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2811 -M-168-001 and NSC-101-2120-M168-001. ",

year = "2013",

month = jan,

day = "28",

doi = "10.1063/1.4789009",

language = "English",

volume = "113",

journal = "Journal of Applied Physics",

issn = "0021-8979",

publisher = "American Institute of Physics Publising LLC",

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AU - Yang, H. C.

AU - Chiu, L. L.

AU - Liao, S. H.

AU - Chen, H. H.

AU - Horng, H. E.

AU - Liu, C. W.

AU - Liu, C. I.

AU - Chen, K. L.

AU - Chen, M. J.

AU - Wang, L. M.

N1 - Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2811 -M-168-001 and NSC-101-2120-M168-001.

PY - 2013/1/28

Y1 - 2013/1/28

N2 - In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

AB - In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

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Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

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