Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang*, L. L. Chiu, S. H. Liao, H. H. Chen, H. E. Horng, C. W. Liu, C. I. Liu, K. L. Chen, M. J. Chen, L. M. Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

Original languageEnglish
Article number043911
JournalJournal of Applied Physics
Issue number4
Publication statusPublished - 2013 Jan 28

ASJC Scopus subject areas

  • General Physics and Astronomy


Dive into the research topics of 'Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields'. Together they form a unique fingerprint.

Cite this