Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang; L. L. Chiu; S. H. Liao; H. H. Chen; H. E. Horng; C. W. Liu; C. I. Liu; K. L. Chen; M. J. Chen; L. M. Wang

doi:10.1063/1.4789009

Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang^*, L. L. Chiu, S. H. Liao, H. H. Chen, H. E. Horng, C. W. Liu, C. I. Liu, K. L. Chen, M. J. Chen, L. M. Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In this work, the spin-spin relaxation rate, 1/T₂, and spin-lattice relaxation rate, 1/T₁, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-T_c superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe₃O₄, which is labeled as Fe₃O₄-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T₂ and 1/T₁ of protons in Fe₃O₄-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T₁ and 1/T₂ of Fe₃O₄-antiCRP are close to that of ferrofluids, which are dextran-coated Fe₃O₄ dispersed in phosphate buffer saline. Characterizing the relaxation of Fe₃O₄-antiCRP can be useful for biomedical applications.

Original language	English
Article number	043911
Journal	Journal of Applied Physics
Volume	113
Issue number	4
DOIs	https://doi.org/10.1063/1.4789009
Publication status	Published - 2013 Jan 28

ASJC Scopus subject areas

General Physics and Astronomy

Access to Document

10.1063/1.4789009

Cite this

@article{d30b789fb10d4ba3bd252e71ea9e339c,

title = "Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields",

abstract = "In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.",

author = "Yang, {H. C.} and Chiu, {L. L.} and Liao, {S. H.} and Chen, {H. H.} and Horng, {H. E.} and Liu, {C. W.} and Liu, {C. I.} and Chen, {K. L.} and Chen, {M. J.} and Wang, {L. M.}",

note = "Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2811 -M-168-001 and NSC-101-2120-M168-001. ",

year = "2013",

month = jan,

day = "28",

doi = "10.1063/1.4789009",

language = "English",

volume = "113",

journal = "Journal of Applied Physics",

issn = "0021-8979",

publisher = "American Institute of Physics Publising LLC",

number = "4",

}

TY - JOUR

T1 - Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

AU - Yang, H. C.

AU - Chiu, L. L.

AU - Liao, S. H.

AU - Chen, H. H.

AU - Horng, H. E.

AU - Liu, C. W.

AU - Liu, C. I.

AU - Chen, K. L.

AU - Chen, M. J.

AU - Wang, L. M.

N1 - Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2811 -M-168-001 and NSC-101-2120-M168-001.

PY - 2013/1/28

Y1 - 2013/1/28

N2 - In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

AB - In this work, the spin-spin relaxation rate, 1/T2, and spin-lattice relaxation rate, 1/T1, of protons' spins induced by biofunctionalized magnetic nanoparticles and ferrofluids are investigated using a high-Tc superconducting quantum interference device-detected magnetometer in ultra-low fields. The biofunctionalized magnetic nanoparticles are the anti-human C-reactive protein (antiCRP) coated onto dextran-coated superparamagnetic iron oxides Fe3O4, which is labeled as Fe3O4-antiCRP. The ferrofluids are dextran-coated iron oxides. It was found that both 1/T2 and 1/T1 of protons in Fe3O4-antiCRP are enhanced by the presence of magnetic nanoparticles. Additionally, both the 1/T1 and 1/T2 of Fe3O4-antiCRP are close to that of ferrofluids, which are dextran-coated Fe3O4 dispersed in phosphate buffer saline. Characterizing the relaxation of Fe3O4-antiCRP can be useful for biomedical applications.

UR - http://www.scopus.com/inward/record.url?scp=84873634283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873634283&partnerID=8YFLogxK

U2 - 10.1063/1.4789009

DO - 10.1063/1.4789009

M3 - Article

AN - SCOPUS:84873634283

SN - 0021-8979

VL - 113

JO - Journal of Applied Physics

JF - Journal of Applied Physics

IS - 4

M1 - 043911

ER -

Relaxation of biofunctionalized magnetic nanoparticles in ultra-low magnetic fields

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this